Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
Abstract
:1. Introduction
2. Results and Discussion
Position | δH (mult., J in Hz) | δC | HMBC |
---|---|---|---|
1-NMe | 4.38 (s) | 46.1 | 2, 6 |
2 | 9.10 (bs) | 148.7 | 1-NMe, 4, 6, COO- |
3 | - | 137.8 | - |
4 | 8.84 (bd, 8.2) | 146.3 | 2, 6, COO−Na+ |
5 | 8.19 (d, 8.2) | 126.6 | 3, 6, 1′ |
6 | - | 163.0 | - |
1′ | 5.13 (dd, 3.3, 9.0) | 69.3 | 6, 2′ |
2′ | 1.72 (m) | 38.9 | 6, 1′, 3′, 4′ |
1.81(m) | |||
3′ | 1.54 (m) | 19.9 | 1′, 2′, 4′ |
1.63 (m) | |||
4′ | 1.00 (t, 7.5) | 14.0 | 2′, 3′ |
–COO- | - | 167.0 | - |
Position | 7 | 8 | |||
---|---|---|---|---|---|
δC | δH (J in Hz) | δC | δH (J in Hz) | HMBC a | |
1 | - | - | - | - | - |
2 | 151.0 | - | 150.7 | - | - |
3 | - | - | - | - | - |
4 | 140.7 | - | 136.8 | - | - |
5 | 117.8 | - | 98.8 | - | - |
6 | 157.4 | - | 153.4 | - | - |
7 | - | - | - | - | - |
8 | 134.5 | 7.79 (s) | 149.6 | - | - |
9 | - | - | - | - | - |
1′ | 92.5 | 6.15 (s) | 91.1 | 5.67 (s) | 4, 8, 2′, 3′, 4′ |
2′ | 75.8 | 3.87 (dd, 5.2, 5.0) | 75.0 | 3.90 (t, 5.3) | 1′, 4′ |
3′ | 70.1 | 4.20 (m) | 70.7 | 4.23 (m) | 5′ |
4′ | 83.7 | 4.55 (m) | 83.6 | 4.46 (m) | - |
5′a | 51.3 | 4.56 (m) | 52.3 | 4.51 (dd, 14.4, 2.4) | 2, 4, 3′, 4′ |
5′b | 51.3 | 3.71 (dd, 15.2, 3.2) | 52.3 | 3.72 (dd,14.4, 2.8) | 2, 4, 3′, 4′ |
OH-2′ | - | 5.62 (d, 5.0) | - | 5.60 (d, 5.3) | - |
OH-3′ | - | 5.62 (bs) | - | 5.35 (d, 7.1) | - |
NH-1 | - | 11.2 | - | 11.3 | 5, 6 |
NH-7 | - | - | - | 11.2 | 4, 5, 8 |
3. Experimental Section
3.1. General Experimental Procedures
3.2. Collection, Extraction and Isolation
3.3. Computational Details
4. Conclusions
Acknowledgments
Supplementary Files
- Samples Availability: Available from the authors.
References
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Menna, M.; Aiello, A.; D'Aniello, F.; Fattorusso, E.; Imperatore, C.; Luciano, P.; Vitalone, R. Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine. Mar. Drugs 2012, 10, 2509-2518. https://doi.org/10.3390/md10112509
Menna M, Aiello A, D'Aniello F, Fattorusso E, Imperatore C, Luciano P, Vitalone R. Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine. Marine Drugs. 2012; 10(11):2509-2518. https://doi.org/10.3390/md10112509
Chicago/Turabian StyleMenna, Marialuisa, Anna Aiello, Filomena D'Aniello, Ernesto Fattorusso, Concetta Imperatore, Paolo Luciano, and Rocco Vitalone. 2012. "Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine" Marine Drugs 10, no. 11: 2509-2518. https://doi.org/10.3390/md10112509