Next Article in Journal
A Sulfated-Polysaccharide Fraction from Seaweed Gracilaria birdiae Prevents Naproxen-Induced Gastrointestinal Damage in Rats
Previous Article in Journal
Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2012, 10(11), 2608-2617; doi:10.3390/md10112608

seco-Briarellinone and Briarellin S, Two New Eunicellin-Based Diterpenoids from the Panamanian Octocoral Briareum asbestinum

1
Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama
2
Department of Chemistry, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), P.O. Box 14-740, 07000, F.D., Mexico
3
Smithsonian Tropical Research Institute, Balboa, Ancon, P.O. Box 0843-03092, Panama
4
Center for Molecular and Cellular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama
*
Author to whom correspondence should be addressed.
Received: 20 August 2012 / Revised: 26 September 2012 / Accepted: 22 October 2012 / Published: 21 November 2012
View Full-Text   |   Download PDF [288 KB, uploaded 24 February 2015]   |  

Abstract

Two new eunicellin-based diterpenes, seco-briarellinone (1) and briarellin S (2), and a known seco-asbestinin (3) have been isolated from the methanolic extract of the common octocoral Briareum asbestinum collected in Bocas del Toro, Caribbean of Panama. The structures and relative stereochemistry of the compounds were defined using extensive spectroscopic analysis including 1D, 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Compounds 1 and 2 displayed anti-inflammatory properties inhibiting nitric oxide (NO) production induced by lipopolisacharide (LPS) in macrophages with an Inhibitory concentration 50% (IC50) of 4.7 μM and 20.3 μM, respectively. This is the first report of briarellin diterpenes containing a ketone group at C-12.
Keywords: Briareum asbestinum; seco-briarellins; briarellin diterpenes; seco-asbestinin diterpenes; anti-inflammatory properties Briareum asbestinum; seco-briarellins; briarellin diterpenes; seco-asbestinin diterpenes; anti-inflammatory properties
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gómez-Reyes, J.F.; Salazar, A.; Guzmán, H.M.; González, Y.; Fernández, P.L.; Ariza-Castolo, A.; Gutiérrez, M. seco-Briarellinone and Briarellin S, Two New Eunicellin-Based Diterpenoids from the Panamanian Octocoral Briareum asbestinum. Mar. Drugs 2012, 10, 2608-2617.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top