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Mar. Drugs 2013, 11(1), 114-123; doi:10.3390/md11010114
Article

A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados

1,†
,
2,†
,
3
,
4
 and
5,*
1 Department of Superintendent, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan 2 Department of Beauty Science, Meiho University, Pingtung 91202, Taiwan 3 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 4 Department of Medical Administration, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan 5 Department of Biological Science and Technology, Meiho University, Pingtung 91202, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 27 November 2012 / Revised: 11 December 2012 / Accepted: 24 December 2012 / Published: 10 January 2013
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Abstract

A new spatane diterpenoid, leptoclalin A (1), along with two previously reported known norcembranoid diterpenes (2 and 3), were isolated from a cultured soft coral Sinularia leptoclados. The structures were determined by extensive spectroscopic analyses and by comparison with the spectral data of related known compounds. Metabolite 1 is rarely found in spatane skeletons reported from soft corals. In addition, compound 1 exhibited weak cytotoxicity towards human tumor cell lines T-47 D and K-562.
Keywords: spatane diterpenoid; soft coral; Sinularia leptoclados spatane diterpenoid; soft coral; Sinularia leptoclados
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tsai, T.-C.; Wu, Y.-J.; Su, J.-H.; Lin, W.-T.; Lin, Y.-S. A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados. Mar. Drugs 2013, 11, 114-123.

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