Next Article in Journal
Beneficial Effects of Marine Algal Compounds in Cosmeceuticals
Previous Article in Journal
Antibacterial Polyketides from the Marine Alga-Derived Endophitic Streptomyces sundarbansensis: A Study on Hydroxypyrone Tautomerism
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2013, 11(1), 136-145; doi:10.3390/md11010136

Steroidal Carboxylic Acids from Soft Coral Paraminabea acronocephala

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
2
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan
3
China Medical University, Taichung 40402, Taiwan
4
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
5
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 November 2012 / Revised: 28 December 2012 / Accepted: 31 December 2012 / Published: 11 January 2013
View Full-Text   |   Download PDF [546 KB, 24 February 2015; original version 24 February 2015]   |  

Abstract

Three new steroidal carboxylic acids, paraminabic acids A–C (13) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC50 values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein. View Full-Text
Keywords: Paraminabea acronocephala; paraminabic acid; soft coral; cytotoxicity; anti-inflammatory activity Paraminabea acronocephala; paraminabic acid; soft coral; cytotoxicity; anti-inflammatory activity
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chao, C.-H.; Wu, Y.-C.; Wen, Z.-H.; Sheu, J.-H. Steroidal Carboxylic Acids from Soft Coral Paraminabea acronocephala . Mar. Drugs 2013, 11, 136-145.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top