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Mar. Drugs 2013, 11(12), 5063-5086; doi:10.3390/md11125063

Fumigaclavine C from a Marine-Derived Fungus Aspergillus Fumigatus Induces Apoptosis in MCF-7 Breast Cancer Cells

1 Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Korea 2 Department of Chemistry, Pukyong National University, Busan 608-737, Korea 3 Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
* Author to whom correspondence should be addressed.
Received: 1 October 2013 / Revised: 30 November 2013 / Accepted: 2 December 2013 / Published: 13 December 2013
(This article belongs to the Special Issue Marine Compounds and Cancer)
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Recently, much attention has been given to discovering natural compounds as potent anti-cancer candidates. In the present study, the anti-cancer effects of fumigaclavine C, isolated from a marine-derived fungus, Aspergillus fumigatus, was evaluated in vitro. In order to investigate the impact of fumigaclavine C on inhibition of proliferation and induction of apoptosis in breast cancer, MCF-7 cells were treated with various concentrations of fumigaclavine C, and fumigaclavine C showed significant cytotoxicity towards MCF-7 cells. Anti-proliferation was analyzed via cell mobility and mitogen-activated protein kinase (MAPK) signaling pathway. In addition, fumigaclavine C showed potent inhibition on the protein and gene level expressions of MMP-2, -9 in MCF-7 cells which were manifested in Western blot and reverse transcription polymerase chain reaction (RT-PCR) results. The apoptosis induction abilities of the fumigaclvine C was studied by analyzing the expression of apoptosis related proteins, cell cycle analysis, DNA fragmentation and molecular docking studies. It was found that fumigaclavine C fragmented the MCF-7 cell DNA and arrested the cell cycle by modulating the apoptotic protein expressions. Moreover, fumigaclavine C significantly down-regulated the NF-kappa-B cell survival pathway. Collectively, data suggest that fumigaclavine C has a potential to be developed as a therapeutic candidate for breast cancer.
Keywords: fumigaclavine C; apoptosis; anti-proliferation; mitochondrial pathway; anti-cancer fumigaclavine C; apoptosis; anti-proliferation; mitochondrial pathway; anti-cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, Y.-X.; Himaya, S.; Dewapriya, P.; Zhang, C.; Kim, S.-K. Fumigaclavine C from a Marine-Derived Fungus Aspergillus Fumigatus Induces Apoptosis in MCF-7 Breast Cancer Cells. Mar. Drugs 2013, 11, 5063-5086.

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