Next Article in Journal
Correction: Wu, S.-L., et al. Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex. Mar. Drugs 2012, 10, 1203–1211
Next Article in Special Issue
Fucoxanthin: A Marine Carotenoid Exerting Anti-Cancer Effects by Affecting Multiple Mechanisms
Previous Article in Journal
Identification of Four New agr Quorum Sensing-Interfering Cyclodepsipeptides from a Marine Photobacterium
Previous Article in Special Issue
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2013, 11(12), 5063-5086; doi:10.3390/md11125063

Fumigaclavine C from a Marine-Derived Fungus Aspergillus Fumigatus Induces Apoptosis in MCF-7 Breast Cancer Cells

1
Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Korea
2
Department of Chemistry, Pukyong National University, Busan 608-737, Korea
3
Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
*
Author to whom correspondence should be addressed.
Received: 1 October 2013 / Revised: 30 November 2013 / Accepted: 2 December 2013 / Published: 13 December 2013
(This article belongs to the Collection Marine Compounds and Cancer)
View Full-Text   |   Download PDF [1299 KB, uploaded 24 February 2015]   |  

Abstract

Recently, much attention has been given to discovering natural compounds as potent anti-cancer candidates. In the present study, the anti-cancer effects of fumigaclavine C, isolated from a marine-derived fungus, Aspergillus fumigatus, was evaluated in vitro. In order to investigate the impact of fumigaclavine C on inhibition of proliferation and induction of apoptosis in breast cancer, MCF-7 cells were treated with various concentrations of fumigaclavine C, and fumigaclavine C showed significant cytotoxicity towards MCF-7 cells. Anti-proliferation was analyzed via cell mobility and mitogen-activated protein kinase (MAPK) signaling pathway. In addition, fumigaclavine C showed potent inhibition on the protein and gene level expressions of MMP-2, -9 in MCF-7 cells which were manifested in Western blot and reverse transcription polymerase chain reaction (RT-PCR) results. The apoptosis induction abilities of the fumigaclvine C was studied by analyzing the expression of apoptosis related proteins, cell cycle analysis, DNA fragmentation and molecular docking studies. It was found that fumigaclavine C fragmented the MCF-7 cell DNA and arrested the cell cycle by modulating the apoptotic protein expressions. Moreover, fumigaclavine C significantly down-regulated the NF-kappa-B cell survival pathway. Collectively, data suggest that fumigaclavine C has a potential to be developed as a therapeutic candidate for breast cancer. View Full-Text
Keywords: fumigaclavine C; apoptosis; anti-proliferation; mitochondrial pathway; anti-cancer fumigaclavine C; apoptosis; anti-proliferation; mitochondrial pathway; anti-cancer
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, Y.-X.; Himaya, S.; Dewapriya, P.; Zhang, C.; Kim, S.-K. Fumigaclavine C from a Marine-Derived Fungus Aspergillus Fumigatus Induces Apoptosis in MCF-7 Breast Cancer Cells. Mar. Drugs 2013, 11, 5063-5086.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top