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Mar. Drugs 2013, 11(2), 455-465; doi:10.3390/md11020455

New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.

School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, China
Analytical and Testing Center, Wenzhou University, Wenzhou 325035, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 6 November 2012 / Revised: 15 January 2013 / Accepted: 29 January 2013 / Published: 6 February 2013
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Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.
Keywords: soft coral; Sinularia; casbane diterpenoids; cytotoxicity; NO inhibition soft coral; Sinularia; casbane diterpenoids; cytotoxicity; NO inhibition

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yin, J.; Zhao, M.; Ma, M.; Xu, Y.; Xiang, Z.; Cai, Y.; Dong, J.; Lei, X.; Huang, K.; Yan, P. New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.. Mar. Drugs 2013, 11, 455-465.

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