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Mar. Drugs 2013, 11(3), 599-610; doi:10.3390/md11030599

Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum

UMR 7200 CNRS, Therapeutic Innovation Laboratory, Faculty of Pharmacy, University of Strasbourg, 64701 Illkirch, France
Department of Material Structure Sciences and Technology, University of Cocody, 01 BP 582, Abidjan, Ivory Coast
Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland
University of Basel, Petersplatz 1, 4003 Basel, Switzerland
CNRS INEE-FRE3484 Marine Mollusks Biology and Associated Ecosystems, University of Caen Basse-Normandie, 14032 Caen Cedex, France
Author to whom correspondence should be addressed.
Received: 12 December 2012 / Revised: 18 January 2013 / Accepted: 7 February 2013 / Published: 26 February 2013
(This article belongs to the Special Issue Marine Algae)
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Organic extracts of 20 species of French seaweed have been screened against Trypanosoma brucei rhodesiense trypomastigotes, the parasite responsible for sleeping sickness. These extracts have previously shown potent antiprotozoal activities in vitro against Plasmodium falciparum and Leishmania donovani. The selectivity of the extracts was also evaluated by testing cytotoxicity on a mammalian L6 cell line. The ethyl acetate extract of the brown seaweed, Bifurcaria bifurcata, showed strong trypanocidal activity with a mild selectivity index (IC50 = 0.53 µg/mL; selectivity index (SI) = 11.6). Bio-guided fractionation led to the isolation of eleganolone, the main diterpenoid isolated from this species. Eleganolone contributes only mildly to the trypanocidal activity of the ethyl acetate extract (IC50 = 45.0 µM, SI = 4.0). However, a selective activity against P. falciparum erythrocytic stages in vitro has been highlighted (IC50 = 7.9 µM, SI = 21.6). View Full-Text
Keywords: eleganolone; linear diterpene; Bifurcaria; Plasmodium falciparum; Trypanosoma eleganolone; linear diterpene; Bifurcaria; Plasmodium falciparum; Trypanosoma

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gallé, J.-B.; Attioua, B.; Kaiser, M.; Rusig, A.-M.; Lobstein, A.; Vonthron-Sénécheau, C. Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum. Mar. Drugs 2013, 11, 599-610.

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