Next Article in Journal
An HPLC Method for Microanalysis and Pharmacokinetics of Marine Sulfated Polysaccharide PSS-Loaded Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles in Rat Plasma
Previous Article in Journal
6″-Debromohamacanthin A, a Bis (Indole) Alkaloid, Inhibits Angiogenesis by Targeting the VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways
Mar. Drugs 2013, 11(4), 1104-1112; doi:10.3390/md11041104

Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece Deceased on 12 May 2010.
* Author to whom correspondence should be addressed.
Received: 25 February 2013 / Revised: 13 March 2013 / Accepted: 19 March 2013 / Published: 2 April 2013
View Full-Text   |   Download PDF [324 KB, uploaded 24 February 2015]   |  


Three new dolastane diterpenes (13) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on extensive analyses of their spectroscopic data, whereas the absolute configuration of metabolite 2 was determined through its chemical conversion to a previously isolated compound of known configuration.
Keywords: Dilophus spiralis; dolastanes; structure elucidation Dilophus spiralis; dolastanes; structure elucidation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Ioannou, E.; Vagias, C.; Roussis, V. Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis. Mar. Drugs 2013, 11, 1104-1112.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert