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Mar. Drugs 2013, 11(5), 1718-1727; doi:10.3390/md11051718

Polyketides from a Marine-Derived Fungus Xylariaceae sp.

Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, Guangdong, China
University of Chinese Academy of Sciences, Beijing 100049, China
New Drug Research & Development Center of North China Pharmaceutical Group Corporation, Shijiazhuang, Hebei 052260, China
Author to whom correspondence should be addressed.
Received: 19 March 2013 / Revised: 22 April 2013 / Accepted: 25 April 2013 / Published: 21 May 2013
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Eighteen polyketides (118) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.
Keywords: Xylariaceae sp.; polyketide; enzyme-inhibitory activity; antifouling activity Xylariaceae sp.; polyketide; enzyme-inhibitory activity; antifouling activity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nong, X.-H.; Zheng, Z.-H.; Zhang, X.-Y.; Lu, X.-H.; Qi, S.-H. Polyketides from a Marine-Derived Fungus Xylariaceae sp.. Mar. Drugs 2013, 11, 1718-1727.

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