Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
Abstract
Five new anthranilic acid derivatives, penipacids A–E (1–5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line. View Full-Text
Figure 1
Supplementary materials
- Supplementary File 1:
Supplementary Materials (PDF, 1906 KB)
- Supplementary File 2:
3D structure (MOL, 2 KB)
Display in MOL Viewer
3D structure generated by CORINA by Molecular Networks. - Supplementary File 3:
MOL-Document (MOL, 2 KB)
Display in MOL Viewer
- Supplementary File 4:
3D structure (MOL, 2 KB)
Display in MOL Viewer
3D structure generated by CORINA by Molecular Networks. - Supplementary File 5:
MOL-Document (MOL, 2 KB)
Display in MOL Viewer
- Supplementary File 6:
3D structure (MOL, 2 KB)
Display in MOL Viewer
3D structure generated by CORINA by Molecular Networks. - Supplementary File 7:
MOL-Document (MOL, 2 KB)
Display in MOL Viewer
- Supplementary File 8:
3D structure (MOL, 1 KB)
Display in MOL Viewer
3D structure generated by CORINA by Molecular Networks. - Supplementary File 9:
MOL-Document (MOL, 1 KB)
Display in MOL Viewer
Share & Cite This Article
Li, C.-S.; Li, X.-M.; Gao, S.-S.; Lu, Y.-H.; Wang, B.-G. Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44. Mar. Drugs 2013, 11, 3068-3076.