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Mar. Drugs 2014, 12(1), 525-546; doi:10.3390/md12010525

Marine Natural Products with P-Glycoprotein Inhibitor Properties

Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
Author to whom correspondence should be addressed.
Received: 22 November 2013 / Revised: 6 January 2014 / Accepted: 7 January 2014 / Published: 22 January 2014
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P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.
Keywords: P-glycoprotein; marine natural products; multidrug resistance P-glycoprotein; marine natural products; multidrug resistance

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lopez, D.; Martinez-Luis, S. Marine Natural Products with P-Glycoprotein Inhibitor Properties. Mar. Drugs 2014, 12, 525-546.

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