Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies
Abstract
:1. Introduction
2. Results and Discussion
Position | δH (J in Hz) | δC, Multiple | 1H-1H COSY | HMBC |
---|---|---|---|---|
1 | 41.9, C | |||
2 | 1.58 m | 46.0, CH | H2-3, H-5 | C-1, -6, -10, -13 |
3α | 1.56 m | 37.2, CH2 | H-2, H-3β | C-1, -2 |
β | 1.35 m | H-2, H-3α | C-2, -4, -14, -15 | |
4 | 33.5, C | |||
5 | 1.55 m | 48.9, CH | H-2, H2-6 | C-2, -14 |
6a | 1.32 m | 25.8, CH2 | H-5, H-6b, H2-7 | C-2, -4, -7 |
b | 1.64 m | H-5, H-6a, H2-7 | C -2, -4, -5, -7, -8 | |
7a | 1.61 m | 34.2, CH2 | H2-6, H-7b | C-5, -6, -8, -9, -12 |
b | 1.78 dd (12.8, 5.6) | H2-6, H-7a | C-5, -8 | |
8 | 52.6, C | |||
9a | 1.68 m | 29.4, CH2 | H-9b, H2-10 | C-7, -8, -10, -11 |
b | 2.14 dd (9.6, 7.6) | H-9a, H2-10 | C-1, -8, -10, -11, -12 | |
10a | 1.44 m | 45.4, CH2 | H2-9, H-10b | n.o. a |
b | 1.68 m | H2-9, H-10a | C-8, -9, -11 | |
11α | 1.59 d (12.8) | 48.9, CH2 | H-11β | C-1, -2, -7, -8, -9, -10, -12 |
β | 1.94 dd (12.8, 2.4) | H-11α | C-9, -10 | |
12 | 184.2, C | |||
13 | 0.93 s | 22.0, CH3 | C-1, -2, -10, -11 | |
14 | 0.98 s | 20.3, CH3 | C-3, -4, -5, -15 | |
15 | 0.98 s | 30.5, CH3 | C-3, -4, -5, -14 |
3. Experimental Section
3.1. General Experimental Procedures
3.2. Animal Material
3.3. Extraction and Isolation
3.4. Human Neutrophil Elastase Release
4. Conclusions
Supplementary Files
Supplementary File 1Acknowledgments
Author Contributions
Conflicts of Interest
References
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Chung, H.-M.; Wang, W.-H.; Hwang, T.-L.; Fang, L.-S.; Wen, Z.-H.; Chen, J.-J.; Wu, Y.-C.; Sung, P.-J. Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies. Mar. Drugs 2014, 12, 5856-5863. https://doi.org/10.3390/md12125856
Chung H-M, Wang W-H, Hwang T-L, Fang L-S, Wen Z-H, Chen J-J, Wu Y-C, Sung P-J. Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies. Marine Drugs. 2014; 12(12):5856-5863. https://doi.org/10.3390/md12125856
Chicago/Turabian StyleChung, Hsu-Ming, Wei-Hsien Wang, Tsong-Long Hwang, Lee-Shing Fang, Zhi-Hong Wen, Jih-Jung Chen, Yang-Chang Wu, and Ping-Jyun Sung. 2014. "Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies" Marine Drugs 12, no. 12: 5856-5863. https://doi.org/10.3390/md12125856