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Mar. Drugs 2014, 12(2), 1013-1022; doi:10.3390/md12021013

Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.

1 Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA 2 Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 19 December 2013 / Revised: 24 January 2014 / Accepted: 24 January 2014 / Published: 14 February 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-13C glucose, and analysis of a 13C–13C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
Keywords: Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus Trididemnum orbiculatum; Solwaraspora; methicillin-resistant Staphylococcus aureus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ellis, G.A.; Wyche, T.P.; Fry, C.G.; Braun, D.R.; Bugni, T.S. Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.. Mar. Drugs 2014, 12, 1013-1022.

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