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Mar. Drugs 2014, 12(5), 2539-2589; doi:10.3390/md12052539

Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases

1
REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal
2
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, Campus University Espinardo, Murcia 30100, Spain
*
Author to whom correspondence should be addressed.
Received: 30 January 2014 / Revised: 10 April 2014 / Accepted: 16 April 2014 / Published: 2 May 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
View Full-Text   |   Download PDF [1670 KB, 24 February 2015; original version 24 February 2015]   |  

Abstract

Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development. This review aims to summarize the potential of drugs derived from marine invertebrates in the field of neuroscience. Therefore, some examples of neuroprotective drugs and neurotoxins will be discussed. Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration. In addition, the neuronal growth promoted by marine drugs, as well as the recent advances in neural tissue engineering, will be highlighted. View Full-Text
Keywords: aragonite; conotoxins; neurodegeneration; neuroinflammation; Aβ peptide; tau hyperphosphorylation; protein kinases; receptors; voltage-dependent ion channels; cyclooxygenases aragonite; conotoxins; neurodegeneration; neuroinflammation; Aβ peptide; tau hyperphosphorylation; protein kinases; receptors; voltage-dependent ion channels; cyclooxygenases
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Grosso, C.; Valentão, P.; Ferreres, F.; Andrade, P.B. Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases. Mar. Drugs 2014, 12, 2539-2589.

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