Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug
Abstract
:1. Introduction: Chemical Defense of Sponges
2. Order Verongida
3. Chemical Structure and Properties of Aeroplysinin-1
4. Reported Antibiotic, Antimicrobial and Antiviral Properties of Aeroplysinin-1 as a Defense Metabolite
Microorganism Species | IC50 (μM) | Reference |
---|---|---|
P. phosphoreum | 3.5 | [32] |
C. wailesii | 5.6 | [32] |
P. minimum | 7.0 | [32] |
HIV-1 | 14.6 | [34] |
5. Aeroplysinin-1 as an Anti-Inflammatory Compound
Cell Line | Treatment (μM) | Target | Effect | Activity | Reference |
---|---|---|---|---|---|
EVLC-2 | 2.5 | MMP-2 | Decrease | Anti-angiogenic | [38] |
HUVEC | 2.5 | MMP-2 | Decrease | Anti-angiogenic | [38] |
HUVEC | 10 | MCP-1 | Decrease | Anti-inflammatory | [38] |
HUVEC | 10 | TSP-1 | Decrease | Anti-inflammatory | [38] |
HUVEC | 10 | COX-2 | Decrease | Anti-inflammatory | [38] |
HUVEC | 20 | Il-1α | Decrease | Anti-inflammatory | [38] |
HUVEC | 20 | MMP-1 | Decrease | Anti-inflammatory | [38] |
RF-24 | 2.5 | MMP-2 | Decrease | Anti-angiogenic | [38] |
BAEC | 10 | Cleaved lamin-A | Increase | Apoptogenic | [39] |
BAEC | 10 | Caspase-2, -3, -8, -9 | Increase | Apoptogenic | [39] |
BAEC | 10 | Cytochrome C | Increase in cytoplasm | Apoptogenic | [39] |
HUVEC | 10 | p-Bad | Increase | Apoptogenic | [39] |
BAEC | 3 | MMP-2 | Decrease | Anti-angiogenic | [40] |
BAEC | 3 | PA | Decrease | Anti-angiogenic | [40] |
BAEC | 3 | PAI | Increase | Anti-angiogenic | [40] |
6. Aeroplysinin-1 as an Anti-Angiogenic Compound
Endothelial Cell Line | IC50 (μM) | Reference |
---|---|---|
HUVEC | 4.7 | [38] |
EVLC-2 | 3.0 | [38] |
RF-24 | 2.8 | [38] |
HMEC | 2.6 | [38] |
BAEC | 2.1 | [40] |
7. Aeroplysinin-1 as an Anti-Tumor Compound
Tumor cell line | IC50 (μM) | Reference |
---|---|---|
HT-1080 | 2.3 | 40 |
HTC-116 | 4.7 | 40 |
HeLa | 3.0 | 43 |
THP-1 | 10.0 | 45 |
NOMO-1 | 17.0 | 45 |
HL-60 | 5.0 | 45 |
8. Is (+)-Aeroplysinin-1 a Receptor Tyrosine Kinase Inhibitor?
9. Conclusion: Potential and Perspectives of (+)-Aeroplysinin-1 as a Novel Multi-Targeted Drug
Acknowledgments
Author Contributions
Conflict of Interest
References
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García-Vilas, J.A.; Martínez-Poveda, B.; Quesada, A.R.; Medina, M.Á. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar. Drugs 2016, 14, 1. https://doi.org/10.3390/md14010001
García-Vilas JA, Martínez-Poveda B, Quesada AR, Medina MÁ. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Marine Drugs. 2016; 14(1):1. https://doi.org/10.3390/md14010001
Chicago/Turabian StyleGarcía-Vilas, Javier A., Beatriz Martínez-Poveda, Ana R. Quesada, and Miguel Ángel Medina. 2016. "Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug" Marine Drugs 14, no. 1: 1. https://doi.org/10.3390/md14010001
APA StyleGarcía-Vilas, J. A., Martínez-Poveda, B., Quesada, A. R., & Medina, M. Á. (2016). Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Marine Drugs, 14(1), 1. https://doi.org/10.3390/md14010001