Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
AbstractA deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. View Full-Text
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Wright, A.E.; Killday, K.B.; Chakrabarti, D.; Guzmán, E.A.; Harmody, D.; McCarthy, P.J.; Pitts, T.; Pomponi, S.A.; Reed, J.K.; Roberts, B.F.; Rodrigues Felix, C.; Rohde, K.H. Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites. Mar. Drugs 2017, 15, 16.
Wright AE, Killday KB, Chakrabarti D, Guzmán EA, Harmody D, McCarthy PJ, Pitts T, Pomponi SA, Reed JK, Roberts BF, Rodrigues Felix C, Rohde KH. Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites. Marine Drugs. 2017; 15(1):16.Chicago/Turabian Style
Wright, Amy E.; Killday, K. B.; Chakrabarti, Debopam; Guzmán, Esther A.; Harmody, Dedra; McCarthy, Peter J.; Pitts, Tara; Pomponi, Shirley A.; Reed, John K.; Roberts, Bracken F.; Rodrigues Felix, Carolina; Rohde, Kyle H. 2017. "Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites." Mar. Drugs 15, no. 1: 16.
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