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Mar. Drugs 2017, 15(12), 381; doi:10.3390/md15120381

Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island

1,2,†
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1,2,†
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1,2
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1,2
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1,2
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1,2,* and 1,2,*
1
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
2
Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 3 November 2017 / Revised: 25 November 2017 / Accepted: 1 December 2017 / Published: 6 December 2017
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Abstract

Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of Aspergillus fumigatus JRJ111048, a fungus isolated from the leaves of the mangrove plant Acrostichum specioum endemic to Hainan island, was found to possess insecticidal activity against Spodoptera litura. Bioactivity-guided isolation lead to the discovery of seven metabolites 17, including one new anhydride derivative aspergide (1), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (2), and five known compounds; α-ethyl glucoside (3), spiculisporic acid B (4), spiculisporic acid C (5), spiculisporic acid (6), and secospiculisporic acid B (7). Their structures were established by NMR spectroscopic and MS analyses, and by comparison of previously reported data. Insecticidal activity against S. litura and antifungal activity of these compounds were investigated. As a result, the new compound 1 showed potent insecticidal activity against newly hatched larvae of S. litura, and compound 4 displayed weak antifungal activity against Candida albicans. View Full-Text
Keywords: Acrostichum specioum; mangrove endophyte; Aspergillus fumigatus; anhydride; fatty acid amide; insecticidal activity; antifungal activity Acrostichum specioum; mangrove endophyte; Aspergillus fumigatus; anhydride; fatty acid amide; insecticidal activity; antifungal activity
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MDPI and ACS Style

Guo, Z.; Gai, C.; Cai, C.; Chen, L.; Liu, S.; Zeng, Y.; Yuan, J.; Mei, W.; Dai, H. Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island. Mar. Drugs 2017, 15, 381.

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