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Table of Contents

Mar. Drugs, Volume 3, Issue 1 (March 2005), Pages 1-21

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Research

Open AccessArticle Amphidinolides B4 and B5, Potent Cytotoxic 26-Membered Macrolides from Dinoflagellate Amphidinium Species
Mar. Drugs 2005, 3(1), 1-8; doi:10.3390/md301001
Received: 6 January 2005 / Accepted: 19 February 2005 / Published: 1 March 2005
Cited by 21 | PDF Full-text (70 KB) | HTML Full-text | XML Full-text
Abstract Two new cytotoxic 26-membered macrolides, amphidinolides B4 (1) and B5 (2), have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-100), and the structures were elucidated on the basis of detailed analyses of 2D NMR data including 13C−13C correlations. Full article
Open AccessArticle Marine Sponge Dysidea herbacea revisited: Another Brominated Diphenyl Ether
Mar. Drugs 2005, 3(1), 9-14; doi:10.3390/md301009
Received: 22 October 2004 / Accepted: 14 March 2005 / Published: 14 March 2005
Cited by 9 | PDF Full-text (95 KB) | HTML Full-text | XML Full-text
Abstract
A pentabrominated phenolic diphenyl ether (1) that has not previously been reported from marine sources has been isolated from Dysidea herbacea collected at Pelorus Island, Great Barrier Reef, Australia. The structure was determined by comparison of NMR data with those of known [...] Read more.
A pentabrominated phenolic diphenyl ether (1) that has not previously been reported from marine sources has been isolated from Dysidea herbacea collected at Pelorus Island, Great Barrier Reef, Australia. The structure was determined by comparison of NMR data with those of known structurally-related metabolites. NMR spectral assignments for (1) are discussed in context with those of three previously reported isomeric pentabrominated phenolic diphenyl ethers. Full article
Open AccessArticle Cytotoxicity and Inhibition of Lymphocyte Proliferation of Fasciculatin, a Linear Furanosesterterpene Isolated from Ircinia variabilis Collected from the Atlantic Coast of Morocco
Mar. Drugs 2005, 3(1), 15-21; doi:10.3390/md301015
Received: 16 February 2005 / Accepted: 15 March 2005 / Published: 15 March 2005
Cited by 11 | PDF Full-text (53 KB) | HTML Full-text | XML Full-text
Abstract Fasciculatin, a furanosesterterpene isolated from the marine sponge Ircinia variabilis from the Atlantic Coast of Morocco, has been evaluated for its influence on a mitogen-induced proliferation of human lymphocytes and growth of human tumor cell lines. Full article

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