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Mar. Drugs 2011, 9(3), 294-306; doi:10.3390/md9030294

Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats

1
Department of Pharmaceutical Biology, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany
2
Department of Aquatic Product Technology, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Jl. Agathis 1, 16680 Darmaga-Bogor, Indonesia
3
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany
*
Author to whom correspondence should be addressed.
Received: 13 January 2011 / Revised: 11 February 2011 / Accepted: 24 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
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Abstract

In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 µg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 µg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product. View Full-Text
Keywords: Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds
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MDPI and ACS Style

Tarman, K.; Lindequist, U.; Wende, K.; Porzel, A.; Arnold, N.; Wessjohann, L.A. Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats. Mar. Drugs 2011, 9, 294-306.

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