Next Article in Journal
Mixed Methods Pilot Study of Sharing Behaviors among Waterpipe Smokers of Rural Lao PDR: Implications for Infectious Disease Transmission
Next Article in Special Issue
Detection of β-Lactamase Residues in Milk by Sandwich ELISA
Previous Article in Journal
Development and Application of a New Grey Dynamic Hierarchy Analysis System (GDHAS) for Evaluating Urban Ecological Security
Previous Article in Special Issue
A Higher Prevalence Rate of Campylobacter in Retail Beef Livers Compared to Other Beef and Pork Meat Cuts
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2013, 10(6), 2109-2119; doi:10.3390/ijerph10062109

Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
Author to whom correspondence should be addressed.
Received: 25 March 2013 / Revised: 17 April 2013 / Accepted: 15 May 2013 / Published: 23 May 2013
(This article belongs to the Special Issue Food Safety and Public Health)
View Full-Text   |   Download PDF [415 KB, uploaded 19 June 2014]


The purpose of this study was to investigate the oxidative damage induced by dietary nickel chloride (NiCl2) in the intestinal mucosa of different parts of the intestine of broilers, including duodenum, jejunum and ileum. A total of 240 one-day-old broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600 or 900 mg/kg NiCl2 during a 42-day experimental period. The results showed that the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), and the ability to inhibit hydroxy radical and glutathione (GSH) content were significantly (p < 0.05 or p < 0.01) decreased in the 300, 600 and 900 mg/kg groups in comparison with those of the control group. In contrast, malondialdehyde (MDA) content was significantly (p < 0.05 or p < 0.01) higher in the 300, 600 and 900 mg/kg groups than that in the control group. It was concluded that dietary NiCl2 in excess of 300 mg/kg could cause oxidative damage in the intestinal mucosa in broilers, which finally impaired the intestinal functions including absorptive function and mucosal immune function. The oxidative damage might be a main mechanism on the effects of NiCl2 on the intestinal health of broilers. View Full-Text
Keywords: broiler; intestinal mucosa; nickel chloride; oxidative damage broiler; intestinal mucosa; nickel chloride; oxidative damage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wu, B.; Cui, H.; Peng, X.; Fang, J.; Zuo, Z.; Deng, J.; Huang, J. Dietary Nickel Chloride Induces Oxidative Intestinal Damage in Broilers. Int. J. Environ. Res. Public Health 2013, 10, 2109-2119.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top