Next Article in Journal
Knowledge, Attitude and Practices (KAP) Survey on Water, Sanitation and Hygiene in Selected Schools in Vhembe District, Limpopo, South Africa
Previous Article in Journal
Road Traffic Noise and Annoyance: A Quantification of the Effect of Quiet Side Exposure at Dwellings
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2013, 10(6), 2271-2281; doi:10.3390/ijerph10062271

Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure

1
Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde 4000, Denmark
2
National Food Institute, Technical University of Denmark, Department of Toxicology and Risk Assessment, Mørkhøj Bygade 19, Søborg 2860, Denmark
3
Centre for Arctic Health and Unit for Cellular & Molecular Toxicology, Department of Public Health, Build. 1260, Bartholins Allé 2, Aarhus University, Aarhus C 8000, Denmark
*
Author to whom correspondence should be addressed.
Received: 12 April 2013 / Revised: 24 May 2013 / Accepted: 27 May 2013 / Published: 4 June 2013
View Full-Text   |   Download PDF [311 KB, uploaded 19 June 2014]   |  

Abstract

Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
Keywords: pesticides; gestational exposure; in vivo experiment; Wistar rats pesticides; gestational exposure; in vivo experiment; Wistar rats
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bossi, R.; Vinggaard, A.M.; Taxvig, C.; Boberg, J.; Bonefeld-Jørgensen, E.C. Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure. Int. J. Environ. Res. Public Health 2013, 10, 2271-2281.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top