Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy
Abstract
:1. Introduction
2. Methods
2.1. Literature Search and Inclusion Criteria
2.2. Data Extraction
2.3. Quality Evaluation
2.4. Statistical Methods
3. Results
3.1. Literature Search and Characters of Involved Studies
3.2. Results of Meta-Analysis
3.3. Sensitivity Analysis
3.4. Publication Bias
3.5. Source of Heterogeneity
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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ALDH2 rs671 and T2DM | |||||||
Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male %) (Case/Control) | Mean Age (Case/Control) | Quality Score |
Maimaitikuerban (1) [18] | 2016 | China | Asian | PCR-RFLP | 96.67%/75.21% | 66/60 | 10 |
Maimaitikuerban (2) [18] | 2016 | China | Asian | PCR-RFLP | 96.67%/64.34% | 66/59 | 10 |
Suzuki (1) [12] | 1996 | Japan | Asian | PCR-RFLP | 70.6%/51.8% | not mentioned | 9 |
Xu (1) [19] | 2010 | China | Asian | PCR-sequencing | 70.8%/63.2% | 61.7 ± 10.6/60.9 ± 10.2 | 12 |
Xu (2) [19] | 2010 | China | Asian | PCR-sequencing | 70.8%/50.8% | 61.7 ± 10.6/61.4 ± 10.0 | 12 |
Yokoyama [20] | 2013 | Japan | Asian | PCR-RFLP | 100%/100% | 57.7 ± 0.5/56.0 ± 0.2 | 9 |
ALDH2 rs671 and DR | |||||||
Author | Year | Country | Ethnicity | Genotyping Methods | Sex Ratio (Male:Female) (Case/Control) | Age (Case/Control) | Quality Score |
Morita [13] | 2013 | Japan | Asian | Taqman | not mentioned | not mentioned | 10 |
Idewaki [21] | 2015 | Japan | Asian | PCR-RFLP | not mentioned | not mentioned | 8 |
Suzuki [22] | 2004 | Japan | Asian | PCR-RFLP | not mentioned | not mentioned | 6 |
Suzuki (2) [12] | 1996 | Japan | Asian | PCR-RFLP | not mentioned | not mentioned | 7 |
ALDH2 rs671 and T2DM | |||||||||
Author | T2DM Patients | Control | HWE of Control | ||||||
Total | *1/*1 | *1/*2 | *2/*2 | Total | *1/*1 | *1/*2 | *2/*2 | ||
Maimaitikuerban (1) [18] | 90 | 47 | 36 | 7 | 114 | 89 | 24 | 1 | 0.655 |
Maimaitikuerban (2) [18] | 90 | 47 | 36 | 7 | 129 | 104 | 24 | 1 | 0.763 |
Suzuki (1) [12] | 170 | 98 | 64 | 8 | 461 | 268 | 161 | 32 | 0.251 |
Xu (1) [19] | 257 | 131 | 111 | 15 | 285 | 177 | 100 | 8 | 0.165 |
Xu (2) [19] | 257 | 131 | 111 | 15 | 309 | 208 | 95 | 6 | 0.195 |
Yokoyama [20] | 383 | 340 | 43 | 0 | 1519 | 1265 | 254 | 0 | <0.0001 |
ALDH2 rs671 and DR | |||||||||
Author | DR Patients | Control | HWE of Control | ||||||
Total | *1/*1 | *1/*2 + *2/*2 | Total | *1/*1 | *1/*2 + *2/*2 | ||||
Morita [13] | 52 | 26 | 26 | 182 | 117 | 65 | N/A | ||
Idewaki [21] | 949 | 539 | 410 | 3451 | 1863 | 1588 | N/A | ||
Suzuki [22] | 51 | 26 | 25 | 107 | 59 | 48 | N/A | ||
Suzuki (2) [12] | 75 | 42 | 33 | 137 | 78 | 59 | N/A |
Genetic Model | ALDH2 rs671 with T2DM | |||||
N | OR (95% CI) | p-Value | I2 (%) | Q Value | ||
*1/*1 vs. *1/*2 | Overall | 6 | 0.64 (0.41, 1.02) | 0.06 | 87 | 37.16 |
Control (CAD) | 2 | 0.72 (0.38, 1.36) | 0.31 | 90 | 3.04 | |
Normal control | 4 | 0.51 (0.28, 0.95) | 0.03 | 67 | 30.02 | |
Chinese | 4 | 0.48 (0.34, 0.67) | <0.0001 | 53 | 6.41 | |
Japanese | 2 | 1.21 (0.71, 2.07) | 0.48 | 78 | 4.48 | |
Large sample | 1 | 1.59 (1.12, 2.24) | 0.009 | N/A | N/A | |
Small sample | 5 | 0.55 (0.38, 0.78) | 0.0009 | 70 | 13.33 | |
*1/*1 vs. *2/*2 | Overall | 6 | 0.31 (0.11, 0.89) | 0.03 | 74 | 15.57 |
Control (CAD) | 2 | 0.23 (0.05, 1.07) | 0.06 | 51 | 2.03 | |
Normal control | 4 | 0.35 (0.07, 1.83) | 0.21 | 83 | 12.01 | |
Chinese | 4 | 0.23 (0.13, 0.42) | <0.00001 | 22 | 3.86 | |
Japanese | 2 | 1.46 (0.65, 3.28) | 0.36 | N/A | N/A | |
Large sample | 1 | Not estimable | N/A | N/A | N/A | |
Small sample | 5 | 0.31 (0.11, 0.89) | 0.03 | 74 | 15.57 | |
*1/*1 vs. *1/*2 + *2/*2 | Overall | 6 | 0.61 (0.37, 1.00) | 0.05 | 89 | 46.23 |
Control (CAD) | 2 | 0.46 (0.23, 0.93) | 0.03 | 76 | 4.17 | |
Normal control | 4 | 0.69 (0.35, 1.37) | 0.29 | 92 | 36.64 | |
Chinese | 4 | 0.43 (0.29, 0.63) | <0.0001 | 65 | 8.58 | |
Japanese | 2 | 1.25 (0.78, 2.01) | 0.36 | 73 | 3.65 | |
Large sample | 1 | 1.59 (1.12, 2.24) | 0.009 | N/A | N/A | |
Small sample | 5 | 0.51 (0.33, 0.77) | 0.002 | 80 | 20.12 | |
*1 vs. *2 | Overall | 6 | 0.72 (0.50, 1.06) | 0.10 | 87 | 37.33 |
Control (CAD) | 2 | 0.49 (0.25, 0.98) | 0.04 | 81 | 5.39 | |
Normal control | 4 | 0.87 (0.54, 1.39) | 0.56 | 88 | 24.50 | |
Chinese | 4 | 0.57 (0.48, 0.68) | <0.00001 | 46 | 5.59 | |
Japanese | 2 | 1.26 (0.87, 1.83) | 0.23 | 65 | 2.83 | |
Large sample | 1 | 1.53 (1.10, 2.14) | 0.01 | N/A | N/A | |
Small sample | 5 | 0.63 (0.45, 0.87) | 0.005 | 77 | 17.64 | |
Genetic Model | ALDH2 rs671 with DR | |||||
N | OR (95% CI) | p-Value | I2 (%) | Q Value | ||
*1/*1 vs. *1/*2 + *2/*2 | Overall | 4 | 1.06 (0.93, 1.22) | 0.37 | 43 | 5.25 |
Large sample | 1 | 0.56 (0.30, 1.04) | 0.06 | N/A | N/A | |
Small sample | 3 | 1.10 (0.96, 1.26) | 0.18 | 0 | 1.73 |
Genotype Model | Number of Studies | OR (95% CI) | p-Value | I2 (%) |
---|---|---|---|---|
*1/*1 vs. *1/*2 | 5 | 0.55 (0.38, 0.78) | 0.0009 | 70% |
*1/*1 vs. *2/*2 | 5 | 0.31 (0.11, 0.89) | 0.03 | 74% |
*1/*1 vs. *1/*2 + *2/*2 | 5 | 0.51 (0.33, 0.77) | 0.002 | 80% |
*1 vs. *2 | 5 | 1.17 (1.01, 1.35) | 0.04 | 47% |
Group | ALDH2 rs671 and T2DM (p-Value) | ALDH2 rs671 and DR (p-Value) | |||
---|---|---|---|---|---|
*1/*1 vs. *1/*2 | *1/*1 vs. *2/*2 | *1/*1 vs. *1/*2 + *2/*2 | *1 vs. *2 | *1/*1 vs. *1/*2 + *2/*2 | |
Begg’s test | 0.260 | 0.806 | 0.452 | 0.452 | 0.308 |
Egger’s test | 0.005 | 0.406 | 0.008 | 0.015 | 0.145 |
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Li, G.-y.; Li, Z.-b.; Li, F.; Dong, L.-p.; Tang, L.; Xiang, J.; Li, J.-m.; Bao, M.-h. Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy. Int. J. Environ. Res. Public Health 2017, 14, 165. https://doi.org/10.3390/ijerph14020165
Li G-y, Li Z-b, Li F, Dong L-p, Tang L, Xiang J, Li J-m, Bao M-h. Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy. International Journal of Environmental Research and Public Health. 2017; 14(2):165. https://doi.org/10.3390/ijerph14020165
Chicago/Turabian StyleLi, Guang-yi, Zi-bo Li, Fang Li, Li-ping Dong, Liang Tang, Ju Xiang, Jian-ming Li, and Mei-hua Bao. 2017. "Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy" International Journal of Environmental Research and Public Health 14, no. 2: 165. https://doi.org/10.3390/ijerph14020165