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Int. J. Environ. Res. Public Health 2017, 14(4), 437; doi:10.3390/ijerph14040437

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

1
Department of Internal Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
2
Department of Family Medicine, Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland
3
Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a (Collegium Pharmaceuticum), 20-093 Lublin, Poland
4
Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a (Collegium Pharmaceuticum), 20-093 Lublin, Poland
5
Individual Medical Practice, Lublin, Ludwika Hirszfelda 5/11, 20-092 Lublin, Poland
6
Department of Trauma Surgery and Emergency Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
7
Department of Ethics and Human Philosophy, Medical University of Lublin, Staszica 4/6 (Collegium Maximum), 20-059 Lublin, Poland
8
Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Icro Maremmani
Received: 22 March 2017 / Revised: 14 April 2017 / Accepted: 16 April 2017 / Published: 21 April 2017
(This article belongs to the Section Environment Health)
View Full-Text   |   Download PDF [428 KB, uploaded 21 April 2017]   |  

Abstract

According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines—interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease. View Full-Text
Keywords: alcohol; liver cirrhosis; selenium; interleukin-6; growth differentiation factor-15 alcohol; liver cirrhosis; selenium; interleukin-6; growth differentiation factor-15
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MDPI and ACS Style

Prystupa, A.; Kiciński, P.; Luchowska-Kocot, D.; Błażewicz, A.; Niedziałek, J.; Mizerski, G.; Jojczuk, M.; Ochal, A.; Sak, J.J.; Załuska, W. Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. Int. J. Environ. Res. Public Health 2017, 14, 437.

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