Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma)
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Madan, V.; Lear, J.T.; Szeimies, R.M. Nonmelanoma skin cancer. Lancet 2010, 375, 673–685. [Google Scholar] [CrossRef]
- Leiter, U.; Eigentler, T.; Garbe, C. Epidemiology of skin cancer. Adv. Exp. Med. Biol. 2014, 810, 120–140. [Google Scholar] [PubMed]
- Lomas, A.; Leonardi-Bee, J.; Bath-Hextall, F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br. J. Dermatol. 2012, 166, 1069–1080. [Google Scholar] [CrossRef] [PubMed]
- Tufaro, A.P.; Azoury, S.C.; Crompton, J.G.; Straughan, D.M.; Reddy, S.; Prasad, N.B.; Shi, G.; Fischer, A.C. Rising incidence and aggressive nature of cutaneous malignancies after transplantation: An update on epidemiology, risk factors, management and surveillance. Surg. Oncol. 2015, 24, 345–352. [Google Scholar] [CrossRef] [PubMed]
- Lipozenčić, J.; Celić, D.; Strnad, M.; Jurakić Tončić, R.; Pašić, A.; Radoš, J.; Znaor, A. Skin cancers in Croatia, 2003–2005: Epidemiologycal study. Coll. Antropol. 2010, 34, 865–869. [Google Scholar] [PubMed]
- Celić, D.; Lipozenčić, J.; Jurakić Tončić, R.; Ledić-Drvar, D.; Marasović, D.; Puizina-Ivić, N.; Čabrijan, L.; Bradamante, M. The incidence of basal cell carcinoma in Croatia: An epidemiologycal study. Acta Dermatovenerol. Croat. 2009, 17, 108–112. [Google Scholar] [PubMed]
- Celić, D.; Lipozenčić, J.; Jurakić Tončić, R.; Pašić, A.; Radoš, J.; Puizina-Ivić, N. Descriptive epidemiology of cutaneous squamous cell carcinoma in Croatia. Coll. Antropol. 2012, 36, 133–137. [Google Scholar] [PubMed]
- Carucci, J.A.; Leffell, D.J. Basal cell carcinoma. In Fitzpatrick’s Dermatology in General Medicine, 6th ed.; Freedberg, I.M., Eisen, A.Z., Wolff, K., Austen, K.F., Goldsmith, L.A., Katz, S.I., Eds.; McGraw-Hill: New York, NY, USA, 2003; Volume 1, pp. 747–754. [Google Scholar]
- Grossman, D.; Leffell, D.J. Squamous cell carcinoma. In Fitzpatrick’s Dermatology in General Medicine, 6th ed.; Freedberg, I.M., Eisen, A.Z., Wolff, K., Austen, K.F., Goldsmith, L.A., Katz, S.I., Eds.; McGraw-Hill: New York, NY, USA, 2003; Volume 1, pp. 737–747. [Google Scholar]
- Daniels, G.; ABO, H. Lewis systems. In Human Blood Groups, 3rd ed.; Daniels, G., Ed.; Wiley-Blackwell: Chicester, UK, 2013; pp. 11–95. [Google Scholar]
- Graziano, S.L.; Tatum, A.H.; Gonchoroff, N.J.; Newman, N.B.; Kohman, L.J. Blood group antigen A and flow cytometric analysis in resected early-stage non-small cell lung cancer. Clin. Cancer Res. 1997, 3, 87–93. [Google Scholar]
- Kay, H.E.; Wallace, D.M. A and B antigens of tumors arising from urinary epithelium. J. Natl. Cancer Inst. 1961, 26, 1349–1365. [Google Scholar]
- Hakomori, S. Antigen structure and genetic basis of histo blood groups A, B and O: Their changes associated with human cancer. Biochim. Biophys. Acta 1999, 1473, 247–266. [Google Scholar] [CrossRef]
- Le Pendu, J.; Marionneau, S.; Cailleau-Thomas, A.; Rocher, J.; Le Moullac-Vaidye, B.; Clement, M. ABH and Lewis histo-blood group antigens in cancer. APMIS 2001, 109, 9–31. [Google Scholar] [CrossRef] [PubMed]
- Ghazizadeh, M.; Kagawa, S.; Kurokawa, K. A, B, O (H) blood group antigen distribution in normal skin and squamous cell carcinoma of the penis. Urol. Res. 1983, 11, 267–269. [Google Scholar] [CrossRef] [PubMed]
- Coon, J.S.; Weinstein, R.S. Blood group-related antigens as markers of malignant potential and heterogeneity in human carcinomas. Hum. Pathol. 1986, 17, 1089–1106. [Google Scholar] [CrossRef]
- Ortntoft, T.F.; Meldgaard, P.; Pedersen, B.; Wolf, H. The blood group ABO gene transcript is down-regulated in human bladder tumors and growth-stimulated urothelial cell lines. Cancer Res. 1996, 56, 1031–1036. [Google Scholar]
- Orntoft, T.F.; Wolf, H.; Watkins, W.M. Activity of the human blood group ABO, Se, H, Le, and X gene- encoded glycosyltransferases in normal and malignant bladder urothelium. Cancer Res. 1988, 48, 4427–4433. [Google Scholar] [CrossRef]
- Ichikawa, D.; Handa, K.; Hakomori, S. Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human tumor cells as correlated with their malignancy. Int. J. Cancer 1998, 76, 284–289. [Google Scholar] [CrossRef]
- Kominato, Y.; Hata, Y.; Takizawa, H.; Tsuchiya, T.; Tsukada, J.; Yamamoto, F. Expression of human histo-blood group ABO genes is dependent upon DNA methylation of the promoter region. J. Biol. Chem. 1999, 274, 37240–37250. [Google Scholar] [CrossRef] [PubMed]
- Chihara, Y.; Sugano, K.; Kobayashi, A.; Kanai, Y.; Yamamoto, H.; Nakazono, M.; Fujimoto, H.; Kakizoe, T.; Fujimoto, K.; Hirohashi, S.; et al. Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene. Lab. Investig. 2005, 85, 895–907. [Google Scholar] [CrossRef]
- Dabelsteen, E.; Gao, S. ABO blood-group antigens in oral cancer. J. Dent. Res. 2005, 84, 21–28. [Google Scholar] [CrossRef]
- Yuan, M.; Itzkowitz, S.H.; Palekar, A.; Shamsuddin, A.M.; Phelps, P.C.; Trump, B.F.; Kim, Y.S. Distribution of blood group antigens A, B, H, Lewis a, and Lewis b in human normal, fetal, and malignant colonic tissue. Cancer Res. 1985, 45, 4499–4511. [Google Scholar]
- Wiley, E.L.; Mendelsohn, G.; Eggleston, J.C. Distribution of carcinoembryonic antigens and blood group substances in adenocarcinoma of the colon. Lab. Investig. 1981, 44, 507–513. [Google Scholar] [PubMed]
- Ernst, C.; Thurin, J.; Atkinson, B.; Wurzel, H.; Herlyn, M.; Stromberg, N.; Civin, C.; Koprowski, H. Monoclonal antibody localization of A and B isoantigens in normal and malignant fixed human tissues. Am. J. Pathol. 1984, 117, 451–461. [Google Scholar] [PubMed]
- Uemura, K.; Hattori, H.; Ono, K.; Ogata, H.; Taketomi, T. Expression of Forssman glycolipid and blood group-related antigens A, Le(x), and Le(y) in human gastric cancer and in fetal tissues. Jpn. J. Exp. Med. 1989, 59, 239–249. [Google Scholar] [PubMed]
- David, L.; Leitao, D.; Sobrinho-Simoes, M.; Bennett, E.P.; White, T.; Mandel, U.; Dabelsteen, E.; Clausen, H. Biosynthetic basis of incompatible histo-blood group A antigen expression: Anti-A transferase antibodies reactive with gastric cancer tissue of type O individuals. Cancer Res. 1993, 53, 5494–5500. [Google Scholar] [PubMed]
- Clausen, H.; Hakomori, S.; Graem, N.; Dabelsteen, E. Incompatible A antigen expressed in tumors of blood group O individuals: Immunochemical, immunohistologic, and enzymatic characterization. J. Immunol. 1986, 136, 326–330. [Google Scholar]
- Sun, W.; Wen, C.P.; Lin, J.; Wen, C.; Pu, X.; Huang, M.; Tsai, M.K.; Tsao, C.K.; Wu, X.; Chow, W.H. ABO blood types and cancer risk—A cohort study of 339,432 subjects in Taiwan. Cancer Epidemiol. 2015, 39, 150–156. [Google Scholar] [CrossRef]
- Li, B.; Tan, B.; Chen, C.; Zhao, L.; Qin, L. Association between the ABO blood group and risk of common cancers. J. Evid. Based Med. 2014, 7, 79–83. [Google Scholar] [CrossRef]
- Tursen, U.; Tiftik, E.N.; Unal, S.; Gunduz, O.; Kaya, T.I.; Camdeviren, H.; Ikizoglu, G. Relationship between ABO blood groups and skin cancers. Dermatol. Online J. 2005, 11, 44. [Google Scholar]
- Cihan, Y.B.; Baykan, H.; Kavuncuoglu, E.; Mutlu, H.; Kucukoglu, M.B.; Ozyurt, K.; Oguz, A. Relationships between skin cancers and blood groups—Link between non-melanomas and ABO/Rh factors. Asian Pac. J. Cancer Prev. 2013, 14, 4199–4203. [Google Scholar] [CrossRef]
- Xie, J.; Qureshi, A.A.; Li, Y.; Han, J. ABO blood group and incidence of skin cancer. PLoS ONE 2010, 5, e11972. [Google Scholar] [CrossRef]
- Ford, E.B. Polymorphysm. Biol. Rev. 1945, 20, 73–88. [Google Scholar] [CrossRef]
- Marionneau, S.; Cailleau-Thomas, A.; Rocher, J.; Le Moullac-Vaidye, B.; Ruvoen, N.; Clement, M.; Le Pendu, J. ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world. Biochimie 2001, 83, 565–573. [Google Scholar] [CrossRef]
- Holborow, E.J.; Brown, P.C.; Glynn, L.E.; Hawes, M.D.; Gresham, G.A.; O’Brien, T.F.; Coombs, R.R. The distribution of the blood group A antigen in human tissues. Br. J. Exp. Pathol. 1960, 41, 430–437. [Google Scholar] [PubMed]
- Popis Stanovništva 2011. g. (Census 2011). Available online: https://www.dzs.hr/Hrv/censuses/census2011/censuslogo.htm (accessed on 26 April 2019). (In Croatian).
- Horsham, C.; Auster, J.; Sendall, M.C.; Stoneham, M.; Youl, P.; Crane, P.; Tenkate, T.; Janda, M.; Kimlin, M. Interventions to decrease skin cancer risk in outdoor workers: update to a 2007 systematic review. BMC Res Notes 2014, 7, 10. [Google Scholar] [CrossRef] [PubMed]
- Honigsmann, H.; Szeimies, R.M.; Knobler, R.; Fitzpatrick, T.B.; Pathak, M.A.; Wolff, K. Photochemotherapy and photodynamic therapy. In Fitzpatrick’s Dermatology in General Medicine, 6th ed.; Freedberg, I.M., Eisen, A.Z., Wolff, K., Austen, K.F., Goldsmith, L.A., Katz, S.I., Eds.; McGraw-Hill: New York, NY, USA, 2003; Volume 2, pp. 2477–2493. [Google Scholar]
- Dusingize, J.C.; Olsen, C.M.; Pandeya, N.P.; Subramaniam, P.; Thompson, B.S.; Neale, R.E.; Green, A.C.; Whiteman, D.C. Cigarette smoking and the risks of basal cell carcinoma and squamous cell carcinoma. J. Investig. Dermatol. 2017, 137, 1700–1708. [Google Scholar] [CrossRef] [PubMed]
- Marionneau, S.; Le Moullac-Vaidye, B.; Le Pendu, J. Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of rat colon carcinoma cells. Glycobiology 2002, 12, 851–856. [Google Scholar] [CrossRef] [PubMed]
- Menoret, A.; Otry, C.; Labarriere, N.; Breimer, M.E.; Piller, F.; Meflah, K.; Le Pendu, J. The expression of carbohydrate blood group antigens correlates with heat resistance. J. Cell Sci. 1995, 108, 1691–1701. [Google Scholar]
- Pavelić, J. Otkrivene dvije nove krvne grupe. (Two new blood groups detected). Medix 2012, 100, 140–144. (In Croatian) [Google Scholar]
- Sheng, L.; Sun, X.; Zhang, L.; Su, D. ABO blood group and nasopharyngeal carcinoma risk in a population of southeast China. Int. J. Cancer 2013, 133, 893–897. [Google Scholar] [CrossRef]
- Ben, Q.; Wang, K.; Yuan, Y.; Li, Z. Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: A case-control study. Int. J. Cancer 2011, 128, 1179–1186. [Google Scholar] [CrossRef] [PubMed]
- Hsiao, L.T.; Liu, N.J.; You, S.L.; Hwang, L.C. ABO blood group and the risk of cancer among middle-aged people in Taiwan. Asia Pac. J. Clin. Oncol. 2015. Available online: https://onlinelibrary.wiley.com/doi/full/10.1111/ajco.12253 (accessed on 14 April 2019).
Control Group, n (%) | NMSCs Group, n (%) | ||
---|---|---|---|
Sex | Female | 240 (54.8) | 241 (46.8) |
Male | 198 (45.2) | 274 (53.2) | |
Tumor localization | Head and neck | 338 (65.6) | |
Trunk | 122 (23.7) | ||
Arms | 47 (9.1) | ||
Legs | 8 (1.6) | ||
Blood group | A | 171 (39) | 196 (38.1) |
B | 77 (17.6) | 89 (17.3) | |
AB | 33 (7.5) | 70 (13.6) | |
O | 157 (35.8) | 160 (31.1) | |
Skin type | I | 0 (0) | 6 (1.1) |
II | 104 (23.7) | 228 (44.2) | |
III | 320 (73.1) | 268 (52.0) | |
IV | 14 (3.2) | 13 (2.5) |
Characteristic | OR (95% CI) | AOR (95% CI) | MOR (95% CI) |
---|---|---|---|
Sex (male vs. female) | 1.36 * (1.06–1.78) | NA | 1.17 (0.86–1.58) |
Age (yrs) | 1.05 * (1.03–1.06) | NA | 1.02 * (1.01–1.04) |
Occupation (outdoors vs. indoors) | 2.1 * (1.62–2.74) | 1.61 * (1.22–2.13) | 1.21 (0.88–1.67) |
Blood group (AB vs. non AB) | 1.93 * (1.25–2.98) | 1.96 * (1.25–3.08) | 2.28 * (1.41–3.69) |
Cigarette smoking | 0.96 (0.73–1.28) | 1.15 (0.85–1.57) | 1.25 (0.9–1.74) |
Skin type II vs. III | 2.63 * (1.96–3.44) | 2.5 * (1.85–3.33) | 1.96 * (1.40–2.72) |
Skin type II vs. IV | 2.38 * (1.07–5.26) | 2.04 (0.95–4.76) | 1.29 (0.55–3.03) |
Solar lentigo | 2.03 * (1.49–2.76) | 1.5 * (1.07–2.09) | 1.66 * (1.15–2.39) |
Actinic keratosis | 5.02 * (3.5–7.19) | 3.66 * (2.49–5.37) | 2.34 * (1.52–3.58) |
Actinic elastosis | 3.63 * (2.73–4.83) | 2.7 * (1.98–3.67) | 1.64 * (1.15–2.36) |
Positive family history | 1.94 * (1.17–3.2) | 2.07 * (1.23–3.46) | 1.62 (0.93–2.84) |
Free time spent indoors and outdoors vs. indoors | 1.46 (0.94–2.26) | 1.6 * (1.02–2.53) | 1.64 * (1.01–2.66) |
Free time spent outdoors vs. indoors | 2.42 * (1.55–3.76) | 2.31 * (1.46–3.66) | 1.73 * (1.05–2.85) |
Sunburns before age 20 | 1.67 * (1.29–2.16) | 1.65 * (1.26–2.16) | 1.27 (0.93–1.75) |
Sunburns after age 20 | 1.75 * (1.35–2.27) | 1.6 * (1.22–2.09) | 1.22 (0.89–1.67) |
Characteristic | MORm | 95%CI (OR) |
---|---|---|
Sex (male vs. female) | 1.23 | 0.92–1.66 |
Age (yrs) | 1.02 * | 1.01–1.03 |
Blood group (AB vs. non AB) | 2.36 * | 1.47–3.8 |
Skin type II vs. III | 2.0 * | 1.44–2.72 |
Skin type II vs. IV | 1.35 | 0.58–3.12 |
Solar lentigo | 1.64 * | 1.15–2.35 |
Actinic keratoses | 2.32 * | 1.52–3.54 |
Actinic elastosis | 1.72 * | 1.21–2.44 |
Free time spent indoors and outdoors vs. indoors | 1.65 * | 1.02–2.67 |
Free time spent outdoors vs. indoors | 1.88 * | 1.15–3.07 |
Sunburns before age 20 | 1.12 * | 1.06–1.9 |
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Celić, D.; Lipozenčić, J.; Kolarić, B.; Ferenčak, G.; Rajković, J.K.; Borlinić, T. Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma). Int. J. Environ. Res. Public Health 2019, 16, 2267. https://doi.org/10.3390/ijerph16132267
Celić D, Lipozenčić J, Kolarić B, Ferenčak G, Rajković JK, Borlinić T. Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma). International Journal of Environmental Research and Public Health. 2019; 16(13):2267. https://doi.org/10.3390/ijerph16132267
Chicago/Turabian StyleCelić, Dijana, Jasna Lipozenčić, Branko Kolarić, Goran Ferenčak, Jolanda Kanižaj Rajković, and Tajana Borlinić. 2019. "Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma)" International Journal of Environmental Research and Public Health 16, no. 13: 2267. https://doi.org/10.3390/ijerph16132267
APA StyleCelić, D., Lipozenčić, J., Kolarić, B., Ferenčak, G., Rajković, J. K., & Borlinić, T. (2019). Association between Blood Group and Nonmelanoma Skin Cancers (Basal Cell Carcinoma and Squamous Cell Carcinoma). International Journal of Environmental Research and Public Health, 16(13), 2267. https://doi.org/10.3390/ijerph16132267