Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Source: NCBI Pathogen Isolates Browsers
2.2. Statistical Analysis
3. Results
3.1. Identification of Common Highly-Occurring AMR Genes in the Studied Countries
3.1.1. Common Frequently-Occurring Antimicrobial-Resistance Genes for Individual Countries for All Years
3.1.2. Historical Profiles of Highly-Occurring AMR Gene Occurrence from 2010 to 2019
3.2. Identification of Common, Highly Occurring Pathogens in the Studied Countries
3.2.1. Common, Highly Occurring Pathogens of Individual Countries for All Years
3.2.2. Historical Profiles of Highly-Occurring Pathogen Occurrence between 2010 and 2018
3.3. Major Meat Carriers Found in the Studied Countries
3.4. Identification of Similarity in Antimicrobial Resistance Occurrence in Studied Countries
4. Discussion
4.1. Absolute Occurrence versus the Relative Occurrence for Studying the Time Trend of Antimicrobial Resistance
4.2. Antimicrobial Usage and the Rising Overall Trend of AMR Genes
4.3. Geographic and Trade Relations between AMR Genes of Different Countries
4.4. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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All Genes | US | UK | South Africa | China | Australia | Canada | Mexico | Brazil |
---|---|---|---|---|---|---|---|---|
tet(A) | tet(A) | tet(A) | tet(A) | tet(A) | tet(A) | tet(A) | tet(A) | tet(A) |
aph(3″)-Ib | aph(3″)-Ib | aph(3″)-Ib | aph(3″)-Ib | aph(3″)-Ib | aph(3″)-Ib | aph(3″)-Ib | aph(3″)-Ib | |
aph(6)-Id | aph(6)-Id | aph(6)-Id | aph(6)-Id | aph(6)-Id | aph(6)-Id | aph(6)-Id | aph(6)-Id | |
blaEC | blaEC | blaEC | blaEC | blaEC | blaEC | blaEC | blaEC | |
blaTEM-1 | blaTEM-1 | blaTEM-1 | blaTEM-1 | blaTEM-1 | blaTEM-1 | blaTEM-1 | blaTEM-1 | |
qacEdelta1 | qacEdelta1 | qacEdelta1 | qacEdelta1 | qacEdelta1 | qacEdelta1 | qacEdelta1 | qacEdelta1 | |
sul1 | sul1 | sul1 | sul1 | sul1 | sul1 | sul1 | sul1 | |
sul2 | sul2 | sul2 | sul2 | sul2 | sul2 | sul2 | sul2 | |
aadA1 | aadA1 | aadA1 | aadA1 | aadA1 | aadA1 | aadA1 | ||
tet(B) | tet(B) | tet(B) | tet(B) | tet(B) | tet(B) | |||
aadA2 | aadA2 | aadA2 | aadA2 | aadA2 | aadA2 | |||
fosX | fosX | fosX | fosX | fosX | fosX | |||
lin | lin | lin | lin | lin | lin | |||
aadA | aadA | aadA | aadA | aadA | ||||
floR | floR | floR | floR | floR | ||||
fosA7 | fosA7 | fosA7 | fosA7 | fosA7 | ||||
aph(3′)-Ia | aph(3′)-Ia | aph(3′)-Ia | aph(3′)-Ia | |||||
dfrA12 | dfrA12 | dfrA12 | dfrA12 | |||||
blaCMY-2 | blaCMY-2 | blaCMY-2 | blaCMY-2 | |||||
bcrB | bcrB | bcrB | ||||||
bcrC | bcrC | bcrC | ||||||
abc-f | abc-f | abc-f | ||||||
sul3 | sul3 | sul3 | ||||||
qnrB19 | qnrB19 | qnrB19 | ||||||
blaCTX-M-55 | blaCTX-M-55 | |||||||
blaOXA-193 | blaOXA-193 | |||||||
catA1 | catA1 | |||||||
mph(A) | mph(A) | |||||||
tet(O) | tet(O) | |||||||
aadA5 | aadA5 | |||||||
ble | ble | |||||||
bleO | bleO | |||||||
fosA3 | fosA3 | |||||||
mcr-1.1 | mcr-1.1 | |||||||
oqxA | oqxA | |||||||
oqxB | oqxB | |||||||
aac(2′)-Ic | aac(2′)-Ic | |||||||
blaA | blaA | |||||||
erm(37) | erm(37) | |||||||
cmlA1 | cmlA1 | |||||||
dfrA5 | dfrA5 | |||||||
qacL | qacL | |||||||
fosA | fosA |
US | UK | South Africa | China | Australia | Canada | Mexico | Brazil |
---|---|---|---|---|---|---|---|
aadA1 | aadA1 | aph(3″)-Ib | aadA2 | blaTEM-1 | aadA1 | aadA2 | aph(3″)-Ib |
blaOXA-193 | aadA2 | aph(6)-Id | blaTEM-1 | dfrA5 | tet(B) | blaTEM-1 | aph(6)-Id |
blaTEM-1 | abc.f | blaEC | ble | sul2 | dfrA12 | blaCMY-2 | |
floR | aph(3″)-Ib | blaTEM-1 | floR | fosA | blaTEM-1 | ||
qacEdelta1 | aph(6)-Id | dfrA5 | mph(A) | qacEdelta1 | floR | ||
sul1 | blaCMY.2 | sul2 | oqxA | sul1 | fosA7 | ||
tet(A) | blaTEM.1 | tet(A) | oqxB | sul2 | sul2 | ||
tet(O) | fosA7 | tet(B) | qacEdelta1 | tet(A) | tet(A) | ||
qacEdelta1 | sul1 | tet(B) | |||||
sul1 | sul2 | ||||||
sul2 | |||||||
tet(A) |
Countries | US | UK | South Africa | China | Australia | Canada | Mexico | Brazil | |
---|---|---|---|---|---|---|---|---|---|
Pathogens | |||||||||
E. coli and Shigella | x | x | x | x | x | x | x | x | |
Salmonella enterica | x | x | x | x | x | x | x | ||
Listeria monocytogenes | x | x | x | x | x | ||||
Klebsiella pneumoniae | x | x | |||||||
Mycobacterium tuberculosis | x | ||||||||
Campylobacter jejuni | x | ||||||||
Pseudomonas aeruginosa | x | ||||||||
Enterobacter | x | ||||||||
Cronobacter | x |
US | UK | South Africa | China | Australia | Canada | Mexico | Brazil |
---|---|---|---|---|---|---|---|
Campylobacter jejuni | Listeria monocytogenes | E. coli and Shigella | Klebsiella pneumoniae | E. coli and Shigella | E. coli and Shigella | E. coli and Shigella | Salmonella enterica |
Salmonella enterica | Salmonella enterica |
Countries | US | UK | South Africa | China | Australia | Canada | Mexico | Brazil | Total Rank | |
---|---|---|---|---|---|---|---|---|---|---|
Meats | ||||||||||
Beef | 2 | 4 | No Data | 4 | 1 | 1 | 1 | 4 | 17 | |
Chicken | 1 | 1 | No Data | 1 | 4 | 2 | 2 | 1 | 12 | |
Pork | 4 | 2 | No Data | 2 | 4 | 4 | 4 | 2 | 22 | |
Turkey | 4 | 4 | No Data | 4 | 4 | 4 | 4 | 4 | 28 |
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Yang, K.; Wang, A.; Fu, M.; Wang, A.; Chen, K.; Jia, Q.; Huang, Z. Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data. Int. J. Environ. Res. Public Health 2020, 17, 472. https://doi.org/10.3390/ijerph17020472
Yang K, Wang A, Fu M, Wang A, Chen K, Jia Q, Huang Z. Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data. International Journal of Environmental Research and Public Health. 2020; 17(2):472. https://doi.org/10.3390/ijerph17020472
Chicago/Turabian StyleYang, Katherine, Annie Wang, Matthew Fu, Aaron Wang, Kevin Chen, Qian Jia, and Zuyi Huang. 2020. "Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data" International Journal of Environmental Research and Public Health 17, no. 2: 472. https://doi.org/10.3390/ijerph17020472