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Int. J. Environ. Res. Public Health 2010, 7(4), 1760-1772; doi:10.3390/ijerph7041760

Maternal Diet, Behaviour and Offspring Skeletal Health

Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
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Received: 24 December 2009 / Revised: 10 March 2010 / Accepted: 15 April 2010 / Published: 16 April 2010
(This article belongs to the Special Issue Health Behavior and Public Health)
View Full-Text   |   Download PDF [137 KB, uploaded 19 June 2014]

Abstract

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk. View Full-Text
Keywords: osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus osteoporosis; epigenetic; early life origins; fracture; bone mass; vitamin D; neonate; fetus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Goodfellow, L.R.; Earl, S.; Cooper, C.; Harvey, N.C. Maternal Diet, Behaviour and Offspring Skeletal Health. Int. J. Environ. Res. Public Health 2010, 7, 1760-1772.

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