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Int. J. Environ. Res. Public Health 2012, 9(12), 4321-4332; doi:10.3390/ijerph9124321

IL-22 mRNA Expression in Blood Samples as a Useful Biomarker for Assessing the Adverse Health Effects of PCBs on Allergic Children

1
Department of Environmental Toxicology, University of California Davis, One Shields Ave, Davis, CA 95616, USA
2
Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu 807-8555, Japan
3
Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
*
Author to whom correspondence should be addressed.
Received: 15 October 2012 / Revised: 15 November 2012 / Accepted: 20 November 2012 / Published: 27 November 2012
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Abstract

To facilitate the assessment of adverse effects of very low concentrations of air pollutants on general populations, we planned to establish a reliable biomarker that is also useful in identifying vulnerable populations. For this purpose we monitored several inflammation markers in blood samples from 2 year old Japanese children (N = 30), and found that those children living close to major highways (<50 m) show higher levels of mRNA expression IL-22 in their blood samples than those living further away (+50 m). This tendency was more pronounced among subjects showing positive IgE against egg and milk. We further examined association between IL-22 mRNA expression and PCB residues and found a number of significant positive correlations between each individual PCB congener and IL-22 expression. To identify the most vulnerable population among those children we selected asthma as a typical allergy-related disease, and could show that there are significant differences in the levels of IL-22 mRNA expression between IgE negative non-asthmatic subject and asthmatic children showing positive IgE reaction toward egg or milk, again. These observations support our main conclusion that IL-22 expression is a sensitive biomarker which is useful in identifying sub-populations of children who are especially vulnerable to air pollution. View Full-Text
Keywords: childhood allergy; biomarkers; environmental pollutants; IL-22; PCB childhood allergy; biomarkers; environmental pollutants; IL-22; PCB
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tsuji, M.; Kawamoto, T.; Koriyama, C.; Matsumura, F. IL-22 mRNA Expression in Blood Samples as a Useful Biomarker for Assessing the Adverse Health Effects of PCBs on Allergic Children. Int. J. Environ. Res. Public Health 2012, 9, 4321-4332.

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