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Materials 2014, 7(5), 3946-3955; doi:10.3390/ma7053946

Antimicrobial Activity of Chitosan-Carbon Nanotube Hydrogels

1
Marine Bioprocess Research Center and Department of Marine-Bio. Convergence Science, Pukyong National University, Busan 608-737, Korea
2
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Kochi682041, India
3
Nanotheranostics Laboratory, Centre for Cellular and Molecular Biology, Hyderabad 500-007, India
*
Author to whom correspondence should be addressed.
Received: 5 November 2013 / Revised: 2 December 2013 / Accepted: 7 May 2014 / Published: 19 May 2014
(This article belongs to the Special Issue Nanocomposites of Polymers and Inorganic Particles 2013)
View Full-Text   |   Download PDF [649 KB, uploaded 19 May 2014]   |  

Abstract

In the present study, we have prepared chitosan-carbon nanotube (Chitosan-CNT) hydrogels by the freeze-lyophilization method and examined their antimicrobial activity. Different concentrations of CNT were used in the preparation of Chitosan-CNT hydrogels. These differently concentrated CNT hydrogels were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electron Microscopy and Optical microscopy. The porosity of the hydrogels were found to be >94%. Dispersion of chitosan was observed in the CNT matrix by normal photography and optical microscopy. The addition of CNT in the composite scaffold significantly reduced the water uptake ability. In order to evaluate antimicrobial activity, the serial dilution method was used towards Staphylococcus aureus, Escherichia coli and Candida tropicalis. The composite Chitosan-CNT hydrogel showed greater antimicrobial activity with increasing CNT concentration, suggesting that Chitosan-CNT hydrogel scaffold will be a promising biomaterial in biomedical applications. View Full-Text
Keywords: marine biomaterials; tissue engineering; chitosan; carbon nanotube; antimicrobial activity marine biomaterials; tissue engineering; chitosan; carbon nanotube; antimicrobial activity
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MDPI and ACS Style

Venkatesan, J.; Jayakumar, R.; Mohandas, A.; Bhatnagar, I.; Kim, S.-K. Antimicrobial Activity of Chitosan-Carbon Nanotube Hydrogels. Materials 2014, 7, 3946-3955.

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