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Viruses 2013, 5(6), 1374-1394; doi:10.3390/v5061374

Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
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Received: 2 April 2013 / Revised: 21 May 2013 / Accepted: 21 May 2013 / Published: 30 May 2013
(This article belongs to the Special Issue Chromatin Control of Viral Infection)
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Abstract

The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.
Keywords: Brd4; BET protein; HPV; papillomavirus; transcription; chromatin; replication; tethering; partitioning; bromodomain Brd4; BET protein; HPV; papillomavirus; transcription; chromatin; replication; tethering; partitioning; bromodomain
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McBride, A.A.; Jang, M.K. Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle. Viruses 2013, 5, 1374-1394.

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