Effect of Disinfection Method and Testing Methodology on the Performance of a Breath-Enhanced Jet Nebulizer
Abstract
:1. Introduction
2. Methods
2.1. Nebulizers and Sterilization
2.2. Study Design
2.3. Testing Procedure
2.4. Biochemical Determination
2.5. Outcome Variables
2.6. Statistical Analysis
3. Results
3.1. Quality Assurance
3.2. Solution Output
3.2.1. Evaluation without Breathing Simulation
3.2.2. Evaluation with Breathing Simulation
3.2.3. Comparisons
3.3. Nebulizers Mass
3.3.1. Evaluation without Breathing Simulation
3.3.2. Evaluation with Breathing Simulation
3.3.3. Comparisons
3.4. Sputtering Time
3.4.1. Evaluation without Breathing Simulation
3.4.2. Evaluation with Breathing Simulation
3.4.3. Comparisons
3.5. Inspiratory Filter
3.5.1. Evaluation without Breathing Simulation
3.5.2. Evaluation with Breathing Simulation
3.5.3. Comparisons
3.6. Expiratory Filter
3.6.1. Evaluation without Breathing Simulation
3.6.2. Evaluation with Breathing Simulation
3.6.3. Comparisons
3.7. Drug Output
3.7.1. Evaluation without Breathing Simulation
3.7.2. Evaluation with Breathing Simulation
3.7.3. Comparisons
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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n | Cleaning/Disinfecting Cycles | 0 | 5 | 10 | 15 | 20 | 30 | 60 | 90 | 120 | 150 | 180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
5 | Cleaning-Breathing simulation | X | X | X | X | X | X | X | X | X | X | X |
Disinfecting-Breathing simulation | X | X | X | X | X | X | X | X | X | X | X | |
5 | Cleaning-No breathing simulation | X | X | X | X | X | X | X | ||||
Disinfecting-No breathing simulation | X | X | X | X | X | X | X |
Variable | Solution Output (mL) | Nebulizer Mass (%) | Sputtering Time (s) | Inspiratory Filter (%) | Expiratory Filter (%) | |||||
---|---|---|---|---|---|---|---|---|---|---|
Cycles | CLEAN | STER | CLEAN | STER | CLEAN | STER | CLEAN | STER | CLEAN | STER |
0 | 1.29 ± 0.12 | 1.22 ± 0.11 | 65.7 ± 4.9 | 68.1 ± 5.5 | 3.6 ± 0.5 | 3.8 ± 0.8 | 16.8 ± 2.6 | 18.0 ± 2.6 | 5.2 ± 1.1 | 6.5 ± 1.4 |
5 | 1.09 ± 0.17 | 1.14 ± 0.15 | 74.5 ± 5.2 | 70.0 ± 4.7 | 3.8 ± 1.3 | 4.6 ± 1.3 | 11.8 ± 2.4 | 12.6 ± 2.2 | 4.5 ± 0.8 | 5.4 ± 1.4 |
10 | 1.43 ± 0.05 | 1.37 ± 0.05 | 60.9 ± 0.7 | 63.4 ± 2.5 | 6.0 ± 0.7 | 6.0 ± 0.7 | 20.1 ± 1.4 | 17.5 ± 1.1 | 7.0 ± 1.1 | 7.0 ± 0.7 |
15 | 1.29 ± 0.25 | 1.21 ± 0.02 | 65.4 ± 9.4 | 64.5 ± 2.0 | 4.4 ± 0.9 | 5.2 ± 0.4 | 16.2 ± 4.6 | 17.2 ± 0.7 | 6.0 ± 2.1 | 6.0 ± 0.6 |
20 | 1.43 ± 0.08 | 1.23 ± 0.15 | 58.9 ± 2.1 | 67.2 ± 5.7 | 6.0 ± 1.0 | 4.4 ± 0.9 | 21.5 ± 1.7 | 18.6 ± 3.3 | 7.8 ± 1.2 | 7.4 ± 1.2 |
30 | 1.54 ± 0.08 | 1.35 ± 0.09 | 56.4 ± 2.6 | 63.0 ± 3.1 | 5.8 ± 0.4 | 5.4 ± 0.5 | 21.2 ± 1.7 | 17.9 ± 2.2 | 8.1 ± 1.5 | 6.8 ± 1.3 |
60 | 1.38 ± 0.09 | 1.33 ± 0.05 | 58.4 ± 4.2 | 60.3 ± 2.4 | 4.6 ± 0.5 | 5.0 ± 0.0 | 22.4 ± 1.4 | 21.2 ± 2.1 | 7.8 ± 1.6 | 8.2 ± 0.7 |
90 | 1.32 ± 0.05 | 1.36 ± 0.06 | 58.2 ± 1.6 | 58.2 ± 2.8 | 4.6 ± 0.9 | 4.4 ± 0.5 | 20.4 ± 0.9 | 20.8 ± 1.9 | 6.8 ± 1.4 | 6.4 ± 1.3 |
120 | 1.27 ± 0.05 | 1.30 ±.0.05 | 60.2 ± 2.7 | 60.7 ± 2.5 | 4.4 ± 0.5 | 4.8 ± 0.4 | 19.1 ± 1.0 | 19.4 ± 2.2 | 6.8 ± 1.0 | 6.1 ± 0.5 |
150 | 1.33 ± 0.05 | 1.32 ± 0.07 | 58.6 ± 1.7 | 58.5 ± 2.6 | 4.2 ± 0.4 | 4.8 ± 0.4 | 20.0 ± 1.4 | 20.9 ± 1.5 | 7.2 ± 1.1 | 6.7 ± 0.8 |
180 | 1.31 ± 0.11 | 1.33 ± 0.07 | 59.7 ± 3.9 | 59.5 ± 2.5 | 4.4 ± 0.5 | 4.8 ± 0.8 | 19.5 ± 2.0 | 19.4 ± 1.2 | 6.3 ± 1.1 | 6.6 ± 1.0 |
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Agoramurthi, K.; Berlinski, A. Effect of Disinfection Method and Testing Methodology on the Performance of a Breath-Enhanced Jet Nebulizer. Pharmaceutics 2024, 16, 16. https://doi.org/10.3390/pharmaceutics16010016
Agoramurthi K, Berlinski A. Effect of Disinfection Method and Testing Methodology on the Performance of a Breath-Enhanced Jet Nebulizer. Pharmaceutics. 2024; 16(1):16. https://doi.org/10.3390/pharmaceutics16010016
Chicago/Turabian StyleAgoramurthi, Kanjanamala, and Ariel Berlinski. 2024. "Effect of Disinfection Method and Testing Methodology on the Performance of a Breath-Enhanced Jet Nebulizer" Pharmaceutics 16, no. 1: 16. https://doi.org/10.3390/pharmaceutics16010016