Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients
Abstract
:1. Introduction
2. Results
2.1. Identification of miRNAs as Potential Prognostic Biomarkers
2.2. The Exprssion Level of Eight Prognostic miRNAs is Associated with the Survival of ccRCC Patients
2.3. Prognostic Value of Combined Eight miRNAs as a Signature in ccRCC Patients
2.4. Function Roles of Eight Prognostic miRNAs in ccRCC
2.5. The Interplay Network Between Twenty-Two TFs and Eight miRNAs
2.6. Prognostic Value of the Combined Nine TFs as a Signature in ccRCC Patients
2.7. Clinical Value of TFs and miRNAs Interplay as a Prognostic Signature in ccRCC Patients
3. Discussion
4. Materials and Method
4.1. Data Sources and Pre-Processing
4.2. Differentially Expressed Gene Analysis
4.3. Survival Analysis and Prognosis Model Establishment
4.4. miRNA Target Prediction and Target Function Analysis
4.5. Prediction of Transcription Factors Regulating miRNAs
4.6. Data Statistics and Visualization
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variables | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
Hazard Ratio (95% CI) | p-Value | Hazard Ratio (95% CI) | p-Value | |
Age | 1.029 (1.014–1.043) | <0.001 | 1.028 (1.012–1.044) | <0.001 |
Gender | 0.920 (0.660–1.284) | 0.624 | 0.832 (0.590–1.172) | 0.292 |
Tumor_pathologic_T | 1.855 (1.556–2.211) | <0.001 | 0.816 (0.525–1.269) | 0.367 |
Metastasis_pathologic_M | 4.671 (3.369–6.475) | <0.001 | 1.514 (0.744–3.078) | 0.253 |
Pathologic_stage_Stage | 1.884 (1.634–2.172) | <0.001 | 1.605 (0.994–2.590) | 0.053 |
Histologic_grade_G | 2.238 (1.800–2.783) | <0.001 | 1.275 (0.996–1.633) | 0.054 |
The eight-miRNA signature | 4.009 (2.725–5.898) | <0.001 | 2.666 (1.768–4.020) | <0.001 |
Variables | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
Hazard Ratio (95% CI) | p-Value | Hazard Ratio (95% CI) | p-Value | |
Age | 1.029 (1.014–1.043) | <0.001 | 1.028 (1.011–1.044) | <0.001 |
Gender | 0.920 (0.6595–1.284) | 0.624 | 0.949 (0.673–1.338) | 0.765 |
Tumor_pathologic_T | 1.855 (1.556–2.211) | <0.001 | 0.840 (0.539–1.311) | 0.443 |
Metastasis_pathologic_M | 4.671 (3.369–6.475) | <0.001 | 1.707 (0.830–3.513) | 0.146 |
Pathologic_stage_Stage | 1.884 (1.634–2.172) | <0.001 | 1.410 (0.865–2.300) | 0.178 |
Histologic_grade_G | 2.238 (1.800–2.783) | <0.001 | 1.420 (1.118–1.803) | 0.765 |
The eleven-gene signature | 4.349 (2.943–6.428) | <0.001 | 2.590 (1.706–3.930) | <0.001 |
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Qin, S.; Shi, X.; Wang, C.; Jin, P.; Ma, F. Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients. Cancers 2019, 11, 1668. https://doi.org/10.3390/cancers11111668
Qin S, Shi X, Wang C, Jin P, Ma F. Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients. Cancers. 2019; 11(11):1668. https://doi.org/10.3390/cancers11111668
Chicago/Turabian StyleQin, Shijie, Xuejia Shi, Canbiao Wang, Ping Jin, and Fei Ma. 2019. "Transcription Factor and miRNA Interplays Can Manifest the Survival of ccRCC Patients" Cancers 11, no. 11: 1668. https://doi.org/10.3390/cancers11111668