Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design, Inclusion Criteria and Data Collection
2.2. ECT Procedure, Response Evaluation and Follow Up
2.3. Statistical Analysis
3. Results
3.1. Patients and Tumor Characteristics
3.2. Procedure and Toxicity
3.3. Tumor Response
3.4. Patient Outcome
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Patient’s Characteristics | CR+PR | SD+PD | p | ||
---|---|---|---|---|---|
n | % | n | % | ||
Age | |||||
<80 | 26 | 86.7 | 4 | 13.3 | 0.716 |
≥80 | 20 | 80.0 | 5 | 20.0 | |
BMI | |||||
<25 | 25 | 86.2 | 4 | 13.8 | 0.170 |
≥25 | 21 | 80.8 | 5 | 19.2 | |
Stage | |||||
FIGO I | 22 | 92.0 | 2 | 8.0 | |
FIGO II | 2 | 66.7 | 1 | 33.3 | 0.442 |
FIGO III | 6 | 86.0 | 1 | 14.0 | |
FIGO IV | 1 | 50.0 | 1 | 50.0 | |
Unknown | 15 | 78.9 | 4 | 21.1 | |
Number of nodules | |||||
=1 | 28 | 93.4 | 2 | 6.6 | 0.063 |
>1 | 18 | 72.0 | 7 | 28.0 | |
Site | |||||
Vulva | 62 | 88.6 | 8 | 11.4 | |
Paraurethral region | 14 | 100.0 | 0 | 0 | 0.167 |
Posterior commisture | 9 | 90.0 | 1 | 10.0 | |
Inguinal region | 1 | 50.0 | 1 | 50.0 | |
Dimension of nodules (cm) | |||||
≤3 | 64 | 90.1 | 7 | 9.9 | 0.702 |
>3 | 20 | 87.0 | 3 | 13.0 | |
Previous treatments | |||||
RT | 1 | 50.0 | 1 | 50.0 | |
Surgery (single or multiple) | 25 | 83.3 | 5 | 16.7 | |
Surgery + RT | 4 | 80.0 | 1 | 20.0 | 0.762 |
Surgery + CHT | 1 | 100.0 | 0 | 0.0 | |
RT + CHT | 5 | 100.0 | 0 | 0.0 | |
Surgery + RT + CHT | 2 | 100.0 | 0 | 0.0 | |
Palliative/no treatment | 8 | 80.0 | 2 | 20.0 |
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Perrone, A.M.; Galuppi, A.; Pirovano, C.; Borghese, G.; Covarelli, P.; De Terlizzi, F.; Ferioli, M.; Cara, S.; Morganti, A.G.; De Iaco, P. Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study. Cancers 2019, 11, 657. https://doi.org/10.3390/cancers11050657
Perrone AM, Galuppi A, Pirovano C, Borghese G, Covarelli P, De Terlizzi F, Ferioli M, Cara S, Morganti AG, De Iaco P. Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study. Cancers. 2019; 11(5):657. https://doi.org/10.3390/cancers11050657
Chicago/Turabian StylePerrone, Anna Myriam, Andrea Galuppi, Cecilia Pirovano, Giulia Borghese, Piero Covarelli, Francesca De Terlizzi, Martina Ferioli, Silvia Cara, Alessio Giuseppe Morganti, and Pierandrea De Iaco. 2019. "Palliative Electrochemotherapy in Vulvar Carcinoma: Preliminary Results of the ELECHTRA (Electrochemotherapy Vulvar Cancer) Multicenter Study" Cancers 11, no. 5: 657. https://doi.org/10.3390/cancers11050657