Radiomic Cancer Hallmarks to Identify High-Risk Patients in Non-Metastatic Colon Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patient Selection
2.2. CT Acquisition Protocol
2.3. CT Scans Segmentation Analysis
2.4. Radiomics Extraction
2.5. Statistical Analysis
3. Results
3.1. Study Population
3.2. Feature Selection and Radiomic Analysis
3.3. Univariate and Multivariate Analyses
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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High Risk (58/108) | N Patients | % | No Risk (50/108) | N Patients | % |
---|---|---|---|---|---|
T | T | ||||
| 1 | 1.7 |
| 1 | 2 |
| 3 | 5.2 |
| 8 | 16 |
| 33 | 56.9 |
| 41/50 | 82 |
| 17 | 29.3 |
| 0/50 | 0 |
| 4 | 6.9 |
| 0/50 | 0 |
LVI | LVI | ||||
| 36/58 | 62 |
| 0/50 | - |
| 22/58 | 38 |
| 50/50 | 100 |
PNI | PNI | ||||
| 4/58 | 6.9 |
| 0/50 | - |
| 54/58 | 93.1 |
| 50/50 | 100 |
BUDDING | BUDDING | ||||
| 34/58 | 58.6 |
| 0/50 | - |
| 24/58 | 41.4 |
| 50/50 | 100 |
Nodes |
| ||||
| 42/58 | 72.5 |
| 50/50 | 100 |
| 4/58 | 6.9 |
| - | - |
| 5/58 | 8.6 |
| - | - |
| 5/58 | 8.6 |
| - | - |
| 2/58 | 3.4 |
| - | - |
MSI | 6/58 | 10.3 | MSI | 10/50 | 20 |
Tumor location | Tumor location | ||||
| 29/58 | 50 |
| 24/50 | 48 |
| 3/58 | 5.2 |
| 3/50 | 6 |
| 26/59 | 44.8 |
| 23/50 | 46 |
Radiomic Features | High Risk | No Risk | ICC | p |
---|---|---|---|---|
Mean ± SD | Mean ± SD | |||
Shape_LeastAxisLength | 23.34 ± 10.43 | 28.38 ± 12.24 | 0.82 | 0.02 |
Shape_Maximum2DDiameterColumn | 43.20 ± 18.48 | 56.74 ± 23.58 | 0.87 | 0.003 |
Shape_Maximum2DDiameterSlice | 49.30 ± 19.09 | 58.63 ± 22.76 | 0.90 | 0.02 |
Shape_MeshVolume | 21,047.06 ± 26,389.25 | 39,659.83 ± 43,204.46 | 0.81 | 0.02 |
Shape_MinorAxisLength | 31.52 ± 11.29 | 38.45 ± 13.76 | 0.91 | 0.004 |
Shape_SurfaceArea | 6507.93 ± 4960.29 | 10,070.17 ± 7988.04 | 0.87 | 0.02 |
Shape_SurfaceVolumeRatio | 0.46 ± 0.19 | 0.38 ± 0.16 | 0.85 | 0.02 |
Shape_Maximum3DDiameter | 56.72 ± 22.63 | 65.57 ± 24.46 | 0.89 | 0.07 |
First Order_VoxelVolume | 21,532.50 ± 26,508.12 | 40,253.22 ± 43,386.76 | 0.91 | 0.009 |
First Order_Energy | 5,272,857.19 ± 6,465,846.03 | 9,614,816.02 ± 10,922,495.83 | 0.90 | 0.03 |
First Order_TotalEnergy | 142,367,144.12 ± 174,577,842.8 | 259,600,032.54 ± 294,907,387.3 | 0.86 | 0.03 |
First Order_Maximum | 149.91 ± 30.88 | 147.02 ± 27.59 | 0.82 | 0.61 |
First Order_Mean | 74.72 ± 15.85 | 72.08 ± 18.64 | 0.88 | 0.81 |
GLCM_Idmn | 0.98 ± 0.01 | 0.98 ± 0.01 | 0.89 | 0.03 |
GLCM_Icm2 | 0.29 ± 0.10 | 0.26 ± 0.09 | 0.85 | 0.08 |
GLCM_SumAverage | 9.55 ± 6.30 | 11.28 ± 7.01 | 0.85 | 0.16 |
GLDM_DependenceNonUniformity | 39.95 ± 42.32 | 70.22 ± 72.70 | 0.87 | 0.02 |
GLDM_GrayLevelNonUniformity | 439.23 ± 537.16 | 877.22 ± 985.89 | 0.86 | 0.01 |
GLDM_LargeDependenceEmphasis | 152.75 ± 71.20 | 185.66 ± 83.91 | 0.88 | 0.02 |
GLDM_SmallDependenceEmphasis | 0.06 ± 0.03 | 0.05 ± 0.02 | 0.90 | 0.03 |
GLDM_SmallDependenceLowGrayLevelEmphasis | 0.02 ± 0.01 | 0.01 ± 0.01 | 0.89 | 0.06 |
GLRLM_GrayLevelNonUniformity | 199.18 ± 202.85 | 342.55 ± 321.67 | 0.88 | 0.02 |
GLRLM_LongRunEmphasis | 4.34 ± 2.62 | 5.61 ± 3.63 | 0.85 | 0.03 |
GLRLM_RunLengthNonUniformityNormalized | 0.47 ± 0.09 | 0.43 ± 0.10 | 0.81 | 0.02 |
GLRLM_RunPercentage | 0.62 ± 0.09 | 0.58 ± 0.11 | 0.82 | 0.04 |
GLRLM_RunVariance | 1.37 ± 1.10 | 2.04 ± 1.92 | 0.87 | 0.04 |
GLRLM_ShortRunEmphasis | 0.70 ± 0.07 | 0.67 ± 0.08 | 0.87 | 0.03 |
GLSZM_ LargeAreaEmphasis | 12,801.55 ± 22,785.03 | 32,877.79 ± 45,848.79 | 0.90 | 0.006 |
GLSZM_ LargeAreaHighGrayLevelEmphasis | 609,276.79 ± 17,04,878.107 | 1,908,734.67 ± 4,536,097.03 | 0.90 | 0.01 |
GLSZM_ LargeAreaLowGrayLevelEmphasis | 693.99 ± 1,234.32 | 1714.36 ± 3566.59 | 0.82 | 0.03 |
GLSZM_SmallAreaEmphasis | 0.58 ± 0.17 | 0.64 ± 0.11 | 0.87 | 0.04 |
GLSZM_ZonePercentage | 0.07 ± 0.04 | 0.05 ± 0.04 | 0.89 | 0.01 |
GLSZM_ZoneVariance | 12,224.58 ± 22,231.55 | 31,666.31 ± 44,755.72 | 0.91 | 0.008 |
GLSZM_ SmallAreaHighGrayLevelEmphasis | 16.35 ± 29.18 | 23.66 ± 31.59 | 0.90 | 0.06 |
NGTDM_ Coarseness | 0.04 ± 0.06 | 0.02 ± 0.04 | 0.88 | 0.01 |
Radiomic Variable | Internal Cohort Radiomic Model | External Cohort | ||
---|---|---|---|---|
OR (95% CI) | Coefficient | OR (95% CI) | Coefficient | |
Shape_SurfaceVolumeRatio | 0.79 (7.82 × 10−22 to 5.42 × 1030) | −0.24 | 227.1 (6.65 × 10−5 to 1,771,984,111) | 5.42 |
GLCM_Idmn | 3,647,282,668 (2.973 × 10−10 to 1.16 × 10+30) | 22.02 | 1.21 × 10+20 (2.07 × 10−28 to 1.05 × 10+74) | 46.25 |
GLRLM_LongRunEmphasis | 0.02 (0.0003 to 1.42) | −3.63 | 58.36 (0.0004 to 183,464,701) | 4.067 |
GLRLM_RunLengthNonUniformityNormalized | 5.99 × 10+14 (3.38 × 10−15 to 1.37 × 10+44) | 34.03 | 8.20 × 10+38 (9.29 × 10−60 to 5.55 × 10+145) | 89.60 |
GLRLM_RunPercentage | 4.7 × 10+18 (0.005 to 1.66 × 10+42) | 42.99 | 1.54 × 10−54 (1.33 × 10−131 to 126,781) | −123.9 |
GLRLM_RunVariance | 1537 (1.24 to 4,121,443) | 7.34 | 1.89 × 10−5 (1 × 10−17 to 36,401) | −10.87 |
GLRLM_ShortRunEmphasis | 3.54 × 10−45 (2.35 × 10−88 to 0.0006) | 102.4 | 735,727,550 (1.49 × 10−77 to 1.94 × 10+100) | 20.42 |
GLSZM_SmallAreaEmphasis | 38.22 (0.49 to 3684) | 3.64 | 0.89 (9.58 × 10−6 to 64,647) | −0.11 |
GLSZM_ZonePercentage | 6.87 × 10−8 (6.04 × 10−19 to 1659) | −16.49 | 42,583,803 (1.39 × 10−22 to 1.75 × 10+40) | 17.57 |
p value | <0.0001 | 0.02 | ||
AUC | 0.73 | 0.75 | ||
Positive Predictive Power | 71.4% | 70% | ||
Negative Predictive Power | 69.7% | 77.3% |
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Caruso, D.; Polici, M.; Zerunian, M.; Del Gaudio, A.; Parri, E.; Giallorenzi, M.A.; De Santis, D.; Tarantino, G.; Tarallo, M.; Dentice di Accadia, F.M.; et al. Radiomic Cancer Hallmarks to Identify High-Risk Patients in Non-Metastatic Colon Cancer. Cancers 2022, 14, 3438. https://doi.org/10.3390/cancers14143438
Caruso D, Polici M, Zerunian M, Del Gaudio A, Parri E, Giallorenzi MA, De Santis D, Tarantino G, Tarallo M, Dentice di Accadia FM, et al. Radiomic Cancer Hallmarks to Identify High-Risk Patients in Non-Metastatic Colon Cancer. Cancers. 2022; 14(14):3438. https://doi.org/10.3390/cancers14143438
Chicago/Turabian StyleCaruso, Damiano, Michela Polici, Marta Zerunian, Antonella Del Gaudio, Emanuela Parri, Maria Agostina Giallorenzi, Domenico De Santis, Giulia Tarantino, Mariarita Tarallo, Filippo Maria Dentice di Accadia, and et al. 2022. "Radiomic Cancer Hallmarks to Identify High-Risk Patients in Non-Metastatic Colon Cancer" Cancers 14, no. 14: 3438. https://doi.org/10.3390/cancers14143438