Opioid-Free Anesthesia and Postoperative Outcomes in Cancer Surgery: A Systematic Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Sources and Search Strategy
2.2. Eligibility Criteria
Study: Randomized Controlled Trials (RCTs)
3. Results
3.1. Search Results
3.2. Outcomes
3.3. Risk of Bias Assessment
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author | Patient | Intervention | Comparator | Outcome(s) | Results |
---|---|---|---|---|---|
Hontoir et al., 2016 [16] | Adult female, breast cancer surgery (total analysed n = 34) | Opioid-free anaesthesia (n = 31): ketamine, lidocaine, clonidine. | Opioid general anaesthesia (n = 33) | Postoperative patient comfort and analgesic, pain and consumption (24 h) | OFA provides better patient satisfaction * and analgesia in PACU and at 24 h. * Statistical but not clinical relevance according to the authors primary hypothesis |
Rangel et al., 2021 [17] | Adult male, prostate cancer surgery (total analysed n = 143) | Opioid-free anaesthesia (n = 72): propofol, ketamine, lidocaine, cisatracurium and TAP block with ropivacaine | Opioid general anaesthesia (n = 71): propofol, ketamine, lidocaine, cisatracurium, TAP block with saline and fentanyl | biochemical recurrence. Postoperative pain, analgesic requirement, time to discharge; survival measured over 6 months to 2 years. | No differences in pain and morphine consumption in PACU, despite higher incidence of moderate/severe pain in the OFA group. No differences in patients’ satisfaction. No difference in AEs, PACU discharge and LOS |
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Bugada, D.; Drotar, M.; Finazzi, S.; Real, G.; Lorini, L.F.; Forget, P. Opioid-Free Anesthesia and Postoperative Outcomes in Cancer Surgery: A Systematic Review. Cancers 2023, 15, 64. https://doi.org/10.3390/cancers15010064
Bugada D, Drotar M, Finazzi S, Real G, Lorini LF, Forget P. Opioid-Free Anesthesia and Postoperative Outcomes in Cancer Surgery: A Systematic Review. Cancers. 2023; 15(1):64. https://doi.org/10.3390/cancers15010064
Chicago/Turabian StyleBugada, Dario, Megan Drotar, Simone Finazzi, Giovanni Real, Luca F. Lorini, and Patrice Forget. 2023. "Opioid-Free Anesthesia and Postoperative Outcomes in Cancer Surgery: A Systematic Review" Cancers 15, no. 1: 64. https://doi.org/10.3390/cancers15010064