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Cancers, Volume 17, Issue 1

January-1 2025 - 159 articles

Cover Story: This review discusses the emerging paradigm that prostate cancer metastasis is driven by a dysregulation of critical molecular machinery that regulates endosome-lysosome homeostasis. Endosome and lysosome compartments have crucial roles in maintaining normal cellular function but are also involved in many hallmarks of cancer pathogenesis, including inflammation, immune response, nutrient sensing, metabolism, proliferation, signalling, and migration. Here we discuss new insight into how alterations in the complex network of trafficking machinery, responsible for the microtubule-based transport of endosomes and lysosomes, may be involved in prostate cancer progression. A better understanding of endosome-lysosome dynamics may facilitate the discovery of novel strategies to detect and manage prostate cancer metastasis and improve patient outcomes. View this paper
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Articles (159)

  • Communication
  • Open Access
2 Citations
2,099 Views
24 Pages

Association of Proteasome Activity and Pool Heterogeneity with Markers Determining the Molecular Subtypes of Breast Cancer

  • Irina Kondakova,
  • Elena Sereda,
  • Evgeniya Sidenko,
  • Sergey Vtorushin,
  • Valeria Vedernikova,
  • Alexander Burov,
  • Pavel Spirin,
  • Vladimir Prassolov,
  • Timofey Lebedev and
  • Alexey Morozov
  • + 1 author

6 January 2025

Background: Proteasomes degrade intracellular proteins. Different proteasome forms were identified. Proteasome inhibitors are used in cancer therapy, and novel drugs directed to specific proteasome forms are developed. Breast cancer (BC) therapy depe...

  • Review
  • Open Access
6 Citations
2,689 Views
14 Pages

Congenital Dermatofibrosarcoma Protuberans—An Update on the Ongoing Diagnostic Challenges

  • Fortunato Cassalia,
  • Andrea Danese,
  • Enrico Cocchi,
  • Silvia Vaienti,
  • Anna Bolzon,
  • Ludovica Franceschin,
  • Roberto Mazzetto,
  • Francesca Caroppo,
  • Davide Melandri and
  • Anna Belloni Fortina

6 January 2025

Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade sarcoma that presents diagnostic challenges due to its resemblance to benign lesions [...]

  • Article
  • Open Access
2 Citations
2,693 Views
24 Pages

Impact of Early Nutritional Intervention During Cancer Treatment on Dietary Intakes and Cardiometabolic Health in Children and Adolescents

  • Josianne Delorme,
  • Andra Dima,
  • Véronique Bélanger,
  • Mélanie Napartuk,
  • Isabelle Bouchard,
  • Caroline Meloche,
  • Daniel Curnier,
  • Serge Sultan,
  • Caroline Laverdière and
  • Daniel Sinnett
  • + 1 author

6 January 2025

Background/Objectives: Pediatric cancer survivors are at greater risk of cardiometabolic complications than their peers. This study evaluates the preliminary impact of the VIE (Valorization, Implication, Education) intervention, which integrates nutr...

  • Editorial
  • Open Access
1,788 Views
7 Pages

Learning from Other Tumors: Pathways for Progress and Overcoming Challenges in Cholangiocarcinoma

  • Giulia Tesini,
  • Chiara Braconi,
  • Lorenza Rimassa and
  • Rocio I. R. Macias

6 January 2025

Cholangiocarcinoma (CCA) is a group of complex and heterogeneous tumors originating from the epithelial cells of bile ducts that can occur in intrahepatic, perihilar, or distal localizations [...]

  • Review
  • Open Access
6 Citations
4,148 Views
45 Pages

Metabolic Signaling in the Tumor Microenvironment

  • Ryan Clay,
  • Kunyang Li and
  • Lingtao Jin

6 January 2025

Cancer cells must reprogram their metabolism to sustain rapid growth. This is accomplished in part by switching to aerobic glycolysis, uncoupling glucose from mitochondrial metabolism, and performing anaplerosis via alternative carbon sources to repl...

  • Review
  • Open Access
7 Citations
3,410 Views
30 Pages

The Role of Chronic Inflammation in Pediatric Cancer

  • Christine Mella,
  • Panogiotis Tsarouhas,
  • Maximillian Brockwell and
  • Hope C. Ball

6 January 2025

Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result in tissue fibrosis and genetic alterations that contribute to the pathogenesis of human...

  • Correction
  • Open Access
900 Views
2 Pages

Correction: Häyrinen et al. The Transcription Factor Twist1 Has a Significant Role in Mycosis Fungoides (MF) Cell Biology: An RNA Sequencing Study of 40 MF Cases. Cancers 2023, 15, 1527

  • Marjaana J. Häyrinen,
  • Jenni Kiiskilä,
  • Annamari Ranki,
  • Liisa Väkevä,
  • Henry J. Barton,
  • Milla E. L. Kuusisto,
  • Katja Porvari,
  • Hanne Kuitunen,
  • Kirsi-Maria Haapasaari and
  • Hanna-Riikka Teppo
  • + 1 author

6 January 2025

In the original publication [...]

  • Article
  • Open Access
1 Citations
1,617 Views
10 Pages

Quality of Nursing Care as Perceived by Patients Treated for Multiple Myeloma in Polish Oncology Units: A Cross-Sectional Study

  • Magdalena Kurek,
  • Tomasz Tatara,
  • Jakub Świtalski,
  • Adam Fronczak,
  • Magdalena Tatara and
  • Anna Augustynowicz

6 January 2025

Background/Objectives: Patient satisfaction is one of the indicators of the quality of nursing care. The purpose of this study is to find out the level of satisfaction of patients with multiple myeloma with the quality of nursing care in oncology uni...

  • Article
  • Open Access
7 Citations
1,732 Views
10 Pages

Benign or Malignant? Ex Vivo Confocal Laser Scanning Microscopy for Bedside Histological Assessment of Melanocytic Lesions

  • Maximilian Deußing,
  • Lisa Buttgereit,
  • Michaela Maurer,
  • Alisa Swarlik,
  • Lara Stärr,
  • Andreas Ohlmann,
  • Katrin Kerl-French,
  • Michael Flaig,
  • Elke C. Sattler and
  • Lars E. French
  • + 1 author

6 January 2025

Objective: Ex vivo confocal laser scanning microscopy (EVCM) is an emerging imaging technique, which offers rapid tissue examination. While the current literature shows promising results in the evaluation of non-melanoma skin cancer, only limited res...

  • Systematic Review
  • Open Access
9 Citations
2,991 Views
17 Pages

Robotic Versus Laparoscopic Adrenalectomy for Adrenal Tumors: An Up-to-Date Meta-Analysis on Perioperative Outcomes

  • Giuseppe Esposito,
  • Barbara Mullineris,
  • Giovanni Colli,
  • Serena Curia and
  • Micaela Piccoli

5 January 2025

Background: Minimally invasive surgery (MIS) for adrenal glands is becoming increasingly developed worldwide and robotic surgery has advanced significantly. Although there are still concerns about the generalization of outcomes and the cost burden, t...

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Cancers - ISSN 2072-6694