The Problems of Radiofrequency Ablation as an Approach for Advanced Unresectable Ductal Pancreatic Carcinoma
Abstract
:1. Introduction
2. Search Strategy
3. Data Extraction
4. Results
Reference | No. of patients | Gender | Age (year) | Site of tumors | Tumor size (cm) | Extension of disease | |||
---|---|---|---|---|---|---|---|---|---|
FemalesNo. (%) | MalesNo. (%) | Median (range) | HeadNo. (%) | Body-tail No. (%) | Median (range) | Locally advancedNo. (%) | MetastasesNo. (%) | ||
Matsui [63] | 20 | 8 (40) | 12 (60) | 59 (45–77) | 11 (55) | 9 (45) | 5.3 (3–10) | 9 (45) | 11 (55) |
Date [30] | 1 | – | 1 | 58 | 1 | – | 3 | – | 1 |
Varshney [36] | 3 | 2 (66.7) | 1 (33.3) | 60 (48–66) | 3 (100) | – | 6.5 (5–8) | 3 (100) | – |
Hadjicostas [64] | 4 | 2 (50) | 2 (50) | 70 (59–79) | 3 (75) | 1 (25) | 8.5 (3–12) | 4 (100) | – |
Wu [39] | 16 | 6 (37.5) | 10 (62.5) | 67 (42–89) | 8 (50) | 8 (50) | NR | 11 (68.7) | 5 (31.3) |
Spiliotis [41] | 12 | 6 (50) | 6(50) | 66.5 (61–79) | 11 (91.7) | 1 (8.3) | 3.7 (3–10) | 8 (66.7) | 4 (33.3) |
Girelli [62] | 50 | 23 (46) | 27 (54) | 64.5 (54.5–74) | 34 (68) | 16 (32) | 4 (3–5) | 50 (100) | – |
Overall | 106 | 47 (44.3) | 59 (56.7) | 64.5 (58–70) | 71 (66.9) | 35 (33.1) | 4.6 (3–12) | 85 (80.1) | 21 (19.9) |
Reference | No. of patients | Approach | Type of associated procedures | No. of passes/size | RFA parameters | ||
---|---|---|---|---|---|---|---|
Surgical No. (%) | Radiological No. (%) | No. (%) | Ratio | Temperature °C median and (range) | Time (min) median and (range) | ||
Matsui [63] | 20 | 20 (100) | – | – | NR | 50 | 15 |
Date [30] | 1 | 1 (100) | – | 1 DB (100) | 1 | 90 | 10 |
Varshney [36] | 3 | 2 (66.7) | 1 (33.3) | – | NR | NR | NR |
Hadjicostas [64] | 4 | 4 (100) | – | 4 CJ * (100) | 0.36 | NR | NR |
Wu [39] | 16 | 16 (100) | – | – | NR | 30 ** | 12 ** |
Spiliotis [41] | 12 | 12 (100) | – | 12 DB (100) | 0.5 | 90 | 6.5 (2–7) |
Girelli [62] | 50 | 50 (100) | – | 19 DB; 8 GB; 3 BB; 1 PJ (62) | NR | 97.5 (90–105) | NR |
Overall | 106 | 105 (95.2) | 1 (4.8) | 48 (45.3) | 0.5 (0.36–1) | 90 (30–105) | 11 (2–15) |
Reference | No. of patients | Morbidity No. of cases (%) | Reoperation No. of cases (%) | Mortality No. of cases (%) | Crude Survival in months Median and (range) |
---|---|---|---|---|---|
Matsui [63] | 20 | 3 (15) | 1 (5) | 3 (15) | 3 |
Date [30] | 1 | 1 (100) | – | – | 3 |
Varshney [36] | 3 | 2 (66.7) | – | – | 9 (1–11) |
Hadjicostas [64] | 4 | – | – | – | 6.5 (3–12 |
Wu [39] | 16 | 7 (43.7) | – | 4 (25) | NR |
Spiliotis [41] | 12 | 4 (33.3) | – | – | 33 (6–39) |
Girelli [62] | 50 | 13 (26) | 3 (6) | 1 (2) | NR |
Overall | 106 | 30 (28.3) | 4 (3.7) | 7 (7.5) | 6.5 (1–33) |
Complication | No. of complication | (%) |
---|---|---|
Gastro-intestinal hemorrhage | 8 | 22.9 |
Pancreatic fistula | 5 | 14.3 |
Biliary leak | 5 | 14.3 |
Portal vein thrombosis | 4 | 11.4 |
Pseudocyst | 3 | 8.6 |
Sepsis | 2 | 5.7 |
Polyuria | 1 | 2.9 |
Ascites | 1 | 2.9 |
Pmeumonia | 1 | 2.9 |
Liver failure | 1 | 2.9 |
Anastomotic ulcer | 1 | 2.9 |
Severe acute pancreatitis | 1 | 2.9 |
Renal failure | 1 | 2.9 |
Delayed gastric emptying | 1 | 2.9 |
Overall | 35 | 100.0 |
5. Discussion
6. Conclusions
References
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Pezzilli, R.; Ricci, C.; Serra, C.; Casadei, R.; Monari, F.; D’Ambra, M.; Corinaldesi, R.; Minni, F. The Problems of Radiofrequency Ablation as an Approach for Advanced Unresectable Ductal Pancreatic Carcinoma. Cancers 2010, 2, 1419-1431. https://doi.org/10.3390/cancers2031419
Pezzilli R, Ricci C, Serra C, Casadei R, Monari F, D’Ambra M, Corinaldesi R, Minni F. The Problems of Radiofrequency Ablation as an Approach for Advanced Unresectable Ductal Pancreatic Carcinoma. Cancers. 2010; 2(3):1419-1431. https://doi.org/10.3390/cancers2031419
Chicago/Turabian StylePezzilli, Raffaele, Claudio Ricci, Carla Serra, Riccardo Casadei, Francesco Monari, Marielda D’Ambra, Roberto Corinaldesi, and Francesco Minni. 2010. "The Problems of Radiofrequency Ablation as an Approach for Advanced Unresectable Ductal Pancreatic Carcinoma" Cancers 2, no. 3: 1419-1431. https://doi.org/10.3390/cancers2031419