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Cancers 2013, 5(3), 890-900; doi:10.3390/cancers5030890

Head and Neck Sarcomas: A Comprehensive Cancer Center Experience

1
Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
2
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
3
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
4
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
*
Author to whom correspondence should be addressed.
Received: 20 May 2013 / Revised: 20 May 2013 / Accepted: 18 June 2013 / Published: 15 July 2013
(This article belongs to the Special Issue Soft Tissue and Bone Sarcoma)
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Abstract

Head/neck sarcomas are rare, accounting for about 1% of head/neck malignancies and 5% of sarcomas. Outcomes have historically been worse in this group, due to anatomic constraints leading to difficulty in completely excising tumors, with high rates of local recurrence. We retrospectively analyzed cases of head/neck soft tissue sarcomas (STS) and osteogenic sarcomas managed in a multi-disciplinary setting at Fox Chase Cancer Center from 1999–2009 to describe clinicopathologic characteristics, treatment, outcomes, and prognostic factors for disease control and survival. Thirty patients with STS and seven patients with osteogenic sarcoma were identified. Most STS were high grade (23) and almost all were localized at presentation (28). Common histologies were synovial cell (6), rhabdomyosarcoma (5), angiosarcoma (4), liposarcoma (4) and leiomyosarcoma (3). The type of primary therapy and disease outcomes were analyzed. Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS). The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.
Keywords: head and neck sarcomas; soft tissue sarcomas; osteogenic sarcomas head and neck sarcomas; soft tissue sarcomas; osteogenic sarcomas
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tejani, M.A.; Galloway, T.J.; Lango, M.; Ridge, J.A.; von Mehren, M. Head and Neck Sarcomas: A Comprehensive Cancer Center Experience. Cancers 2013, 5, 890-900.

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