Cancers 2014, 6(1), 79-111; doi:10.3390/cancers6010079
The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations
1
Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos#3-09, Singapore 138673, Singapore
2
National University of Singapore (NUS), Department of Biochemistry, Singapore 117597, Singapore
*
Author to whom correspondence should be addressed.
Received: 14 November 2013 / Revised: 24 December 2013 / Accepted: 3 January 2014 / Published: 13 January 2014
(This article belongs to the Special Issue Cell Cycle Deregulation in Cancers)
Abstract
The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.Keywords:
cell cycle; cancer; liver; hepatocellular carcinoma; cyclin-dependent kinases; CKI; cyclins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style
Bisteau, X.; Caldez, M.J.; Kaldis, P. The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations. Cancers 2014, 6, 79-111.