CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas
Abstract
:1. Introduction
2. Immunology in the CNS
3. Immunotherapy in Cancer
3.1. Monoclonal Antibodies (mAb)
3.2. Adoptive Cell Transfer (ACT)
3.3. Immune Modulators
3.4. Vaccines
4. Evidence for CD8 T Cell-Independent Tumor Clearance in Glioma
4.1. CD4 T Cells
4.2. Natural Killer (NK) Cells
4.3. B Cells
4.4. Macrophages
4.5. Neutrophils
4.6. Myeloid-Derived Suppressor Cells (MDSC)
4.7. Mast Cells
5. Conclusions: Rethinking the Strategy
Author Contributions
Conflicts of Interest
References
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Murphy, K.A.; Griffith, T.S. CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas. Cancers 2016, 8, 71. https://doi.org/10.3390/cancers8080071
Murphy KA, Griffith TS. CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas. Cancers. 2016; 8(8):71. https://doi.org/10.3390/cancers8080071
Chicago/Turabian StyleMurphy, Katherine A., and Thomas S. Griffith. 2016. "CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas" Cancers 8, no. 8: 71. https://doi.org/10.3390/cancers8080071