Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features
Abstract
:1. Introduction
2. New Category of MiT Family tRCC
3. Clinical Characteristics of MiT Family tRCC
4. Pathological Characteristics of MiT Family tRCC
4.1. Xp11 tRCC
4.2. t(6;11) RCC
5. Immunohistochemical Characteristics of MiT Family tRCC
6. How to Diagnose MiT Family tRCC
6.1. Immunohistochemistry
6.2. Break-Apart FISH
6.3. RT-PCR, 5′-RACE, and Karyotyping
7. RCC with Chromosome 6p Amplification
8. ALK-rearranged RCC
9. Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
5′-RACE | 5′-rapid amplification of cDNA ends |
bHLH | basic helix-loop-helix |
FFPE | formalin-fixed paraffin-embedded |
FISH | fluorescence in situ hybridization |
lncRNA | long non-coding RNA |
PEComa | perivascular epithelioid cell tumor |
RCC | renal cell carcinoma |
RT-PCR | reverse transcriptase-polymerase chain reaction |
TCGA | The Cancer Genome Atlas |
tRCC | translocation renal cell carcinoma |
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RCC subtypes | TFE3 | TFEB | Cathepsin K | HMB45 | Melan A | CAIX | CK7 | AMACR |
---|---|---|---|---|---|---|---|---|
Xp11 tRCC | + | ‒ | +/‒ | ‒/f+ | f+/‒ | ‒/f+ | ‒ | + |
t(6;11) RCC | ‒ | + | + | +/‒ | + | ‒/f+ | ‒ | + |
Clear cell RCC | ‒ | ‒ | ‒ | ‒ | ‒ | + | ‒ | ‒ |
Papillary RCC | ‒ | ‒ | ‒ | ‒ | ‒ | ‒ | + | +/‒ |
Chromophobe RCC | ‒ | ‒ | ‒ | ‒ | ‒ | ‒ | + | ‒ |
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Inamura, K. Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features. Cancers 2017, 9, 111. https://doi.org/10.3390/cancers9090111
Inamura K. Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features. Cancers. 2017; 9(9):111. https://doi.org/10.3390/cancers9090111
Chicago/Turabian StyleInamura, Kentaro. 2017. "Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features" Cancers 9, no. 9: 111. https://doi.org/10.3390/cancers9090111