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Pathogens 2013, 2(3), 436-445; doi:10.3390/pathogens2030436

The Functional Role of Prion Protein (PrPC) on Autophagy

Ilsong Institute of Life Science, Hallym University, 1605-4 Gwanyang-dong, Dongan-gu, Anyang, Gyeonggi-do 431-060, Republic of Korea
Department of Microbiology, College of Medicine, Hallym University, 1 Okcheon-dong, Chuncheon, Kangwon-do 200-702, Republic of Korea
Author to whom correspondence should be addressed.
Received: 2 May 2013 / Revised: 11 June 2013 / Accepted: 18 June 2013 / Published: 26 June 2013
(This article belongs to the Special Issue Prions)
View Full-Text   |   Download PDF [351 KB, 8 July 2013; original version 26 June 2013]   |  


Cellular prion protein (PrPC) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrPC is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrPC.
Keywords: prion; Prnp-deficient; prion diseases; autophagy; autophagic flux; oxidative stress prion; Prnp-deficient; prion diseases; autophagy; autophagic flux; oxidative stress

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shin, H.-Y.; Oh, J.-M.; Kim, Y.-S. The Functional Role of Prion Protein (PrPC) on Autophagy. Pathogens 2013, 2, 436-445.

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