The Functional Role of Prion Protein (PrPC) on Autophagy
AbstractCellular prion protein (PrPC) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrPC is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrPC.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Shin, H.-Y.; Oh, J.-M.; Kim, Y.-S. The Functional Role of Prion Protein (PrPC) on Autophagy. Pathogens 2013, 2, 436-445.
Shin H-Y, Oh J-M, Kim Y-S. The Functional Role of Prion Protein (PrPC) on Autophagy. Pathogens. 2013; 2(3):436-445.Chicago/Turabian Style
Shin, Hae-Young; Oh, Jae-Min; Kim, Yong-Sun. 2013. "The Functional Role of Prion Protein (PrPC) on Autophagy." Pathogens 2, no. 3: 436-445.