SARS-CoV-2 Omicron BA.2.75 Variant May Be Much More Infective than Preexisting Variants Based on In Silico Model
Abstract
:1. Introduction
2. Materials and Methods
Determination of the Absolute Evolutionary Distances between the Wuhan Variant and Variant Spike Protein Genes (S Genes), and Docking Affinities of the Different Spike Proteins with ACE2
3. Results
Absolute Evolutionary Distances for S Gene Variants and Results of Docking of the RBD with ACE2 Protein
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Variants | Wuhan | Alpha | Beta | Gamma | Delta | Omicron BA.1 | Omicron BA.2 | Omicron BA.4/5 | Omicron BA.2.75 |
---|---|---|---|---|---|---|---|---|---|
Pango Lineage | B | B.1.1.7 | B.1.351 | P.1 | B.1.617.2 | B.1.1.529/BA.1 | B.1.1.529/BA.2 | B.1.1.529/BA.4/5 | B.1.1.529/BA.2.75 |
Absolute evolutionary distance of the S gene (from Wuhan) × 10−3 | - | 2.07 | 2.07 | 3.55 | 3.26 | 10.72 | 8.31 | 9.21 | 10.99 |
Docking affinity (ratio per Wuhan) | 1 | 1.18 | 1.23 | 1.31 | 2.10 | 1.55 | 2.46 | 2.15 | 2.90 |
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Sugano, A.; Takaoka, Y.; Kataguchi, H.; Ohta, M.; Kimura, S.; Araki, M.; Morinaga, Y.; Yamamoto, Y. SARS-CoV-2 Omicron BA.2.75 Variant May Be Much More Infective than Preexisting Variants Based on In Silico Model. Microorganisms 2022, 10, 2090. https://doi.org/10.3390/microorganisms10102090
Sugano A, Takaoka Y, Kataguchi H, Ohta M, Kimura S, Araki M, Morinaga Y, Yamamoto Y. SARS-CoV-2 Omicron BA.2.75 Variant May Be Much More Infective than Preexisting Variants Based on In Silico Model. Microorganisms. 2022; 10(10):2090. https://doi.org/10.3390/microorganisms10102090
Chicago/Turabian StyleSugano, Aki, Yutaka Takaoka, Haruyuki Kataguchi, Mika Ohta, Shigemi Kimura, Masatake Araki, Yoshitomo Morinaga, and Yoshihiro Yamamoto. 2022. "SARS-CoV-2 Omicron BA.2.75 Variant May Be Much More Infective than Preexisting Variants Based on In Silico Model" Microorganisms 10, no. 10: 2090. https://doi.org/10.3390/microorganisms10102090