Cis- and Trans-Encoded Small Regulatory RNAs in Bacillus subtilis
Abstract
:1. Introduction
2. Base-Pairing sRNAs
2.1. Cis-Encoded sRNAs (Bona Fide Antisense RNAs) in B. subtilis
2.1.1. Antitoxins in Type I Toxin–Antitoxin Systems
2.1.2. Other Cis-Encoded sRNAs in B. subtilis
2.2. Trans-Encoded sRNAs in B. subtilis
2.2.1. SR1
2.2.2. FsrA
2.2.3. RoxS
2.2.4. RosA
2.2.5. RnaC
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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sRNA | sRNA Length | Mechanism of Action of sRNA | Target RNA | Target Gene Function | Regulation, Peculiarity |
---|---|---|---|---|---|
RatA | 222 nt | RD | txpA | Toxin | Glucose dependent |
SR4 | 180 nt | RD + TI | bsrG | Toxin | Temperature dependent |
SR5 | 163 nt | RD | bsrE | Toxin | Multistress responsive |
SR6 | 100/215 nt * | RD TI | yonT yoyJ | Toxin Toxin | Multistress responsive |
as-bsrH | 200 nt | RD | bsrH | Toxin | Multistress responsive |
S25 | ≈1350 nt | unknown | yabE | Autolysin | sRNA under control of σM and σX |
S1559 | 667 nt | unknown | gdpP | c-di-AMP PD | sRNA under σD control |
S1326 | 700–2200 nt # | unknown | cwlO | Autolysin | sRNA under σB control |
S1290 | 300–3800 nt # | T interference | opuB | Choline transporter | sRNA under σB control |
SR7 | 185/259 nt | T interference | rpsD | Ribosomal protein S4 | sRNA under σB control; dual-function antisense RNA |
sRNA | sRNA Length | Mechanism of Action of sRNA | Target RNA | Target Gene Function | Regulation |
---|---|---|---|---|---|
SR1 | 205 nt | TI TI | ahrC kinA | Arginine catabolism Sporulation initiation | CcpN, CcpA, sporulation |
FsrA | 84 nt | TI TI TI TI TI TI | sdhCAB citB gltA lutABC dctP leuCD | Iron sparing response Aconitase Glutamate synthase Iron-sulfur oxidase Dicarboxylate permease Leucine biosynthesis | Fur, iron; Some targets need FbpA, B, or C |
RnaC | 125 nt ? | RD + TI ? | abrB | Transition state regulation | Growth phase |
RoxS | 115 nt | TI + RD TI + RD RD RS + TA | ppnKB sucC acsA yflS | Redox regulation, TCA cycle, Acetyl-CoA synthetase Malate transporter | ResD (NO), Rex (malate) |
RosA | 92/128/ 193/225 nt * | Seq | RoxS FsrA | Trans-encoded sRNA Trans-encoded sRNA | CcpA |
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Brantl, S.; Müller, P. Cis- and Trans-Encoded Small Regulatory RNAs in Bacillus subtilis. Microorganisms 2021, 9, 1865. https://doi.org/10.3390/microorganisms9091865
Brantl S, Müller P. Cis- and Trans-Encoded Small Regulatory RNAs in Bacillus subtilis. Microorganisms. 2021; 9(9):1865. https://doi.org/10.3390/microorganisms9091865
Chicago/Turabian StyleBrantl, Sabine, and Peter Müller. 2021. "Cis- and Trans-Encoded Small Regulatory RNAs in Bacillus subtilis" Microorganisms 9, no. 9: 1865. https://doi.org/10.3390/microorganisms9091865