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Brain Sci. 2017, 7(4), 44; doi:10.3390/brainsci7040044

A Comprehensive Diverse ‘-omics’ Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome

Department of Pathological Biochemistry, Division of Pathological Science, Kyoto Pharmaceutical University, 5 Misasagi Nakauchi-cho, Ymashina-ku, Kyoto 607-8414, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Bruno Meloni
Received: 28 March 2017 / Revised: 17 April 2017 / Accepted: 18 April 2017 / Published: 21 April 2017
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Abstract

Diverse ‘-omics’ technologies permit the comprehensive quantitative profiling of a variety of biological molecules. Comparative ‘-omics’ analyses, such as transcriptomics and proteomics, are powerful and useful tools for unraveling the molecular pathomechanisms of various diseases. As enhanced oxidative stress has been demonstrated in humans and mice with Down syndrome (DS), a redox proteomic analysis is useful for understanding how enhanced oxidative stress aggravates the state of individuals with oxidative stress-related disorders. In this review, ‘-omics’ analyses in humans with DS and mouse models of DS are summarized, and the molecular dissection of this syndrome is discussed. View Full-Text
Keywords: proteomics; transcriptomics; Down syndrome; mouse models proteomics; transcriptomics; Down syndrome; mouse models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ishihara, K.; Akiba, S. A Comprehensive Diverse ‘-omics’ Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome. Brain Sci. 2017, 7, 44.

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