Next Article in Journal
Caspase-1 Dependent IL-1β Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant, PCEP
Previous Article in Journal
Therapeutic Vaccine Strategies against Human Papillomavirus
Previous Article in Special Issue
Nonclinical Development of BCG Replacement Vaccine Candidates
Article Menu

Export Article

Open AccessReview
Vaccines 2014, 2(2), 463-499; doi:10.3390/vaccines2020463

Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations

1
Biosafety and Biotechnology Unit, Scientific Institute of Public Health, 14 Juliette Wytsman Street, Brussels 1050, Belgium
2
Immunology Unit, Scientific Institute of Public Health, 642 Engeland Street, Brussels 1180, Belgium
*
Authors to whom correspondence should be addressed.
Received: 13 February 2014 / Revised: 24 April 2014 / Accepted: 6 May 2014 / Published: 16 June 2014
(This article belongs to the Special Issue Tuberculosis Vaccines)
View Full-Text   |   Download PDF [723 KB, uploaded 16 June 2014]   |  

Abstract

Novel efficient vaccines are needed to control tuberculosis (TB), a major cause of morbidity and mortality worldwide. Several TB vaccine candidates are currently in clinical and preclinical development. They fall into two categories, the one of candidates designed as a replacement of the Bacille Calmette Guérin (BCG) to be administered to infants and the one of sub-unit vaccines designed as booster vaccines. The latter are designed as vaccines that will be administered to individuals already vaccinated with BCG (or in the future with a BCG replacement vaccine). In this review we provide up to date information on novel tuberculosis (TB) vaccines in development focusing on the risk assessment of candidates composed of genetically modified organisms (GMO) which are currently evaluated in clinical trials. Indeed, these vaccines administered to volunteers raise biosafety concerns with respect to human health and the environment that need to be assessed and managed.
Keywords: tuberculosis; vaccine candidate; clinical trial; genetically modified organism; risk assessment; biosafety tuberculosis; vaccine candidate; clinical trial; genetically modified organism; risk assessment; biosafety
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leunda, A.; Baldo, A.; Goossens, M.; Huygen, K.; Herman, P.; Romano, M. Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations. Vaccines 2014, 2, 463-499.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top