Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane

Bergmann, Michèle; Freisl, Monika; Hartmann, Katrin; Speck, Stephanie; Truyen, Uwe; Zablotski, Yury; Mayr, Matthias; Wehner, Astrid

doi:10.3390/vaccines8030547

Open AccessArticle

Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane

by

Michèle Bergmann

^1,*,

Monika Freisl

¹,

Katrin Hartmann

¹,

Stephanie Speck

²,

Uwe Truyen

²,

Yury Zablotski

¹

,

Matthias Mayr

¹ and

Astrid Wehner

¹

Clinic of Small Animal Medicine, LMU Munich, 80539 Munich, Germany

²

Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04103 Leipzig, Germany

^*

Author to whom correspondence should be addressed.

Vaccines 2020, 8(3), 547; https://doi.org/10.3390/vaccines8030547

Submission received: 26 August 2020 / Revised: 14 September 2020 / Accepted: 15 September 2020 / Published: 19 September 2020

(This article belongs to the Special Issue Infectious Diseases Immunology)

Download Review Reports Versions Notes

Abstract

It is unknown how dogs with hyperadrenocorticism (HAC) respond to vaccination. This study measured antibodies against canine parvovirus (CPV) in dogs with HAC treated with trilostane before and after CPV vaccination, and compared the immune response to that from healthy dogs. Eleven dogs with HAC, and healthy age-matched control dogs (n = 31) received a modified-live CPV vaccine. Antibodies were determined on days 0, 7, and 28 by hemagglutination inhibition. Univariate analysis was used to compare the immune response of dogs with HAC and healthy dogs. Pre-vaccination antibodies (≥10) were detected in 100% of dogs with HAC (11/11; 95% CI: 70.0–100) and in 93.5% of healthy dogs (29/31; 95% CI: 78.3–99.2). No ≥4-fold increase in antibody titer was observed in dogs with HAC while in 22.6% of healthy dogs, a ≥4-fold titer increase was observed (7/31; 95% CI: 11.1–40.1). Mild vaccine-associated adverse events (VAAEs) were detected in 54.5% of dogs with HAC (6/11; 95% CI: 28.0–78.8) and in 29.0% of healthy dogs (9/31; 95% CI: 15.9–46.8). There was neither a significant difference in presence of pre-vaccination antibodies (p = 1.000), or response to vaccination (p = 0.161), nor in the occurrence of VAAEs (p = 0.158). Immune function of dogs with HAC treated with trilostane seems comparable to that of healthy dogs.

Keywords: CPV; HAC; cushing; protection; immunosuppression; MLV; titer

Share and Cite

MDPI and ACS Style

Bergmann, M.; Freisl, M.; Hartmann, K.; Speck, S.; Truyen, U.; Zablotski, Y.; Mayr, M.; Wehner, A. Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane. Vaccines 2020, 8, 547. https://doi.org/10.3390/vaccines8030547

AMA Style

Bergmann M, Freisl M, Hartmann K, Speck S, Truyen U, Zablotski Y, Mayr M, Wehner A. Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane. Vaccines. 2020; 8(3):547. https://doi.org/10.3390/vaccines8030547

Chicago/Turabian Style

Bergmann, Michèle, Monika Freisl, Katrin Hartmann, Stephanie Speck, Uwe Truyen, Yury Zablotski, Matthias Mayr, and Astrid Wehner. 2020. "Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane" Vaccines 8, no. 3: 547. https://doi.org/10.3390/vaccines8030547

APA Style

Bergmann, M., Freisl, M., Hartmann, K., Speck, S., Truyen, U., Zablotski, Y., Mayr, M., & Wehner, A. (2020). Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane. Vaccines, 8(3), 547. https://doi.org/10.3390/vaccines8030547

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Antibody Response to Canine Parvovirus Vaccination in Dogs with Hyperadrenocorticism Treated with Trilostane

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI