Correction: Langeskov-Christensen, M., et al. Aerobic Capacity Is Not Associated with Most Cognitive Domains in Patients with Multiple Sclerosis—A Cross-Sectional Investigation. Journal of Clinical Medicine 2018, 7, 272
by
, , ,
Martin Langeskov-Christensen
1,*
,
Søren Eskildsen
1,
Egon Stenager
2,
Henrik Boye Jensen
2,3,
Helle Hvilsted Nielsen
4,
Thor Petersen
5,
Lars Grøndahl Hvid
1,
Päivi Hämäläinen
6,
Lisbet Marstrand
7 and
Ulrik Dalgas
1 1
Section for Sport Science, Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark
2
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark/MS-Clinic of Southern Jutland (Sønderborg, Kolding, Esbjerg), Department of Neurology, Hospital of Southern Denmark, 6400 Sønderborg, Denmark
3
Brain and Nerve Diseases, Department of Neurology, Hospital Lillebaelt, 6000 Kolding, Denmark
4
The Multiple Sclerosis Clinic, Department of Neurology, Odense University Hospital, 5000 Odense C, Denmark
5
The Multiple Sclerosis Clinic, Department of Neurology, Aarhus University Hospital, 8000 Aarhus C, Denmark
6
Masku Neurological Rehabilitation Centre, 21250 Masku, Finland
7
The Danish Multiple Sclerosis Centre, Department of Neurology, Rigshospitalet, 2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 574; https://doi.org/10.3390/jcm8050574
Submission received: 25 April 2019
/
Accepted: 26 April 2019
/
Published: 26 April 2019
The authors wish to make the following corrections to this paper [1].
The authors have identified a statistical error regarding the number of cognitively impaired patients since incorrect standard deviations of the healthy reference population were unfortunately used when calculating the z-scores of the individual cognitive tests; the correct number of patients categorized as cognitively impaired therefore has to be adjusted from 29 (34.5%) to 37 (44.0%). Due to this error, all affected statistical analyses were performed again. As a consequence of this change, the cognitively impaired group (CI group) no longer had a lower aerobic capacity when compared to the cognitively nonimpaired group (CN group). All other results were unchanged. Hence, this finding is now in line with the overall findings of the regression analyses. Moreover, it has no impact on the conclusions of our paper.
Accordingly,
should be replaced with
Table 2.
Subject characteristics.
| Total Sample | Range | CI Group | CN Group | |
|---|---|---|---|---|
| Sex (men/women) | 35/49 | 15/14 | 20/35 | |
| Age (years) | 44.9 ± 9.4 | (23–64) | 48.8 ± 8.1 | 42.9 ± 9.4 * |
| Height (cm) | 173.9 ± 10.0 | (154–198) | 174.3 ± 10.9 | 173.7 ± 9.6 |
| Weight (kg) | 76.0 ± 16.8 | (46–153) | 74.3 ± 16.2 | 77.0 ± 17.2 |
| Fat percent (%) | 28.4 ± 9.1 | (10–47) | 25.7 ± 8.4 | 29.8 ± 9.3 * |
| BMI (kg/m2) | 25.0 ± 4.2 | (17–39) | 24.2 ± 3.8 | 25.4 ± 4.3 |
| VO2-max (L/min) | 2.13 ± 0.6 | (0.9–3.6) | 1.9 ± 0.7 | 2.2 ± 0.5 * |
| Aerobic Capacity (ml O2/min/kg) | 28.4 ± 7.3 | (11–42) | 25.9 ± 6.7 | 29.7 ± 7.3 * |
| RER (VCO2/VO2) | 1.21 ± 0.08 | (1.01–1.39) | 1.20 ± 0.09 | 1.21 ± 0.08 |
| HRmax (beats/min) | 168 ± 15.8 | (124–200) | 162.7 ± 15.7 | 171.4 ± 15.1 * |
| RPE | 17.2 ± 1.4 | (13–20) | 17.0 ± 1.5 | 17.4 ± 1.3 |
| Education (years) | 16.5 ± 2.8 | (10–25) | 15.1 ± 2.8 | 17.2 ± 2.5 * |
| DMT use (yes/no) | 69/15 | 21/8 | 48/7 | |
| EDSS | 2.67 ± 1.44 | (0–6) | 3.2 ± 1.4 | 2.4 ± 1.4 * |
| MS type (RR, PP, SP) | 73/6/5 | 24/3/2 | 49/3/3 | |
| Disease duration (years) | 9.9 ± 7.1 | (0–38) | 11.2 ± 8.2 | 9.3 ± 6.4 |
Values are means ± SD, (range) or number of subjects. CI: Cognitively impaired, CN Cognitively nonimpaired, VO2-max: Peak oxygen consumption, RER: Respiratory Exchange Ratio, HRmax: Maximal Heart Rate, RPE: Rating of Perceived Exhaustion, DMT: Disease Modifying Treatment EDSS: Expanded Disability Status Scale, RR: Relapsing-Remitting, PP: Primary progressive, SP: Secondary Progressive. * CN significantly different from the CI group.
Table 2.
Subject characteristics.
| Total Sample | Range | CI Group | CN Group | |
|---|---|---|---|---|
| Sex (men/women) | 35/49 | 19/18 | 16/31 | |
| Age (years) | 44.9 ± 9.4 | (23–64) | 47.5 ± 8.8 | 42.9 ± 9.4 * |
| Height (cm) | 173.9 ± 10.0 | (154–198) | 174.6 ± 10.9 | 173.4 ± 9.3 |
| Weight (kg) | 76.0 ± 16.8 | (46–153) | 74.4 ± 14.9 | 77.3 ± 18.2 |
| Fat percent (%) | 28.4 ± 9.1 | (10–47) | 26.0 ± 8.9 | 30.3 ± 9.0 * |
| BMI (kg/m2) | 25.0 ± 4.2 | (17–39) | 24.3 ± 3.7 | 25.6 ± 4.5 |
| VO2-max (L/min) | 2.13 ± 0.6 | (0.9–3.6) | 2.0 ± 0.7 | 2.2 ± 0.6 |
| Aerobic Capacity (ml O2/min/kg) | 28.4 ± 7.3 | (11–42) | 26.9 ± 6.7 | 29.5 ± 7.6 |
| RER (VCO2/VO2) | 1.21 ± 0.08 | (1.01–1.39) | 1.21 ± 0.08 | 1.21 ± 0.08 |
| HRmax (beats/min) | 168 ± 15.8 | (124–200) | 164.6 ± 14.2 | 171.4 ± 16.5 * |
| RPE | 17.2 ± 1.4 | (13–20) | 17.1 ± 1.4 | 17.4 ± 1.4 |
| Education (years) | 16.5 ± 2.8 | (10–25) | 15.2 ± 2.6 | 17.5 ± 2.5 * |
| DMT use (yes/no) | 69/15 | 28/9 | 41/6 | |
| EDSS | 2.67 ± 1.44 | (0–6) | 3.1 ± 1.4 | 2.4 ± 1.4 * |
| MS type (RR, PP, SP) | 73/6/5 | 31/3/3 | 42/3/2 | |
| Disease duration (years) | 9.9 ± 7.1 | (0–38) | 10.6 ± 8.5 | 9.4 ± 5.8 |
Values are means ± SD, (range) or number of subjects. CI: Cognitively impaired, CN Cognitively nonimpaired, VO2-max: Peak oxygen consumption, RER: Respiratory Exchange Ratio, HRmax: Maximal Heart Rate, RPE: Rating of Perceived Exhaustion, DMT: Disease Modifying Treatment EDSS: Expanded Disability Status Scale, RR: Relapsing-Remitting, PP: Primary progressive, SP: Secondary Progressive. * CN significantly different from the CI group.
The authors apologize for any inconvenience caused to the readers by these changes.
Reference
- Langeskov-Christensen, M.; Eskildsen, S.; Stenager, E.; Boye Jensen, H.; Hvilsted Nielsen, H.; Petersen, T.; Grondahl Hvid, L.; Hamalainen, P.; Marstrand, L.; Dalgas, U. Aerobic capacity is not associated with most cognitive domains in patients with multiple sclerosis-a cross-sectional investigation. J. Clin. Med. 2018, 7, 272. [Google Scholar] [CrossRef] [PubMed]
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Langeskov-Christensen, M.; Eskildsen, S.; Stenager, E.; Boye Jensen, H.; Hvilsted Nielsen, H.; Petersen, T.; Grøndahl Hvid, L.; Hämäläinen, P.; Marstrand, L.; Dalgas, U. Correction: Langeskov-Christensen, M., et al. Aerobic Capacity Is Not Associated with Most Cognitive Domains in Patients with Multiple Sclerosis—A Cross-Sectional Investigation. Journal of Clinical Medicine 2018, 7, 272. J. Clin. Med. 2019, 8, 574. https://doi.org/10.3390/jcm8050574
AMA Style
Langeskov-Christensen M, Eskildsen S, Stenager E, Boye Jensen H, Hvilsted Nielsen H, Petersen T, Grøndahl Hvid L, Hämäläinen P, Marstrand L, Dalgas U. Correction: Langeskov-Christensen, M., et al. Aerobic Capacity Is Not Associated with Most Cognitive Domains in Patients with Multiple Sclerosis—A Cross-Sectional Investigation. Journal of Clinical Medicine 2018, 7, 272. Journal of Clinical Medicine. 2019; 8(5):574. https://doi.org/10.3390/jcm8050574
Chicago/Turabian StyleLangeskov-Christensen, Martin, Søren Eskildsen, Egon Stenager, Henrik Boye Jensen, Helle Hvilsted Nielsen, Thor Petersen, Lars Grøndahl Hvid, Päivi Hämäläinen, Lisbet Marstrand, and Ulrik Dalgas. 2019. "Correction: Langeskov-Christensen, M., et al. Aerobic Capacity Is Not Associated with Most Cognitive Domains in Patients with Multiple Sclerosis—A Cross-Sectional Investigation. Journal of Clinical Medicine 2018, 7, 272" Journal of Clinical Medicine 8, no. 5: 574. https://doi.org/10.3390/jcm8050574
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