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Biology 2012, 1(2), 165-174; doi:10.3390/biology1020165

Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, MD 20892, USA
Received: 20 June 2012 / Revised: 15 July 2012 / Accepted: 16 July 2012 / Published: 23 July 2012
(This article belongs to the Special Issue Structural and Molecular Biology of HIV)
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Post-transcriptional regulation of HIV-1 gene expression is largely governed by the activities of the viral Rev protein. In this minireview, the multiple post-transcriptional activities of Rev in the export of partially spliced and unspliced HIV-1 RNAs from the nucleus to the cytoplasm, in the translation of HIV-1 transcripts, and in the packaging of viral genomic RNAs are reviewed in brief.
Keywords: Rev; CRM1; DDX3; RNA export; RNA translation; RNA packaging Rev; CRM1; DDX3; RNA export; RNA translation; RNA packaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jeang, K.-T. Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev. Biology 2012, 1, 165-174.

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