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Biology 2012, 1(2), 165-174; doi:10.3390/biology1020165
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Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, MD 20892, USA
Received: 20 June 2012 / Revised: 15 July 2012 / Accepted: 16 July 2012 / Published: 23 July 2012
(This article belongs to the Special Issue Structural and Molecular Biology of HIV)
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Abstract

Post-transcriptional regulation of HIV-1 gene expression is largely governed by the activities of the viral Rev protein. In this minireview, the multiple post-transcriptional activities of Rev in the export of partially spliced and unspliced HIV-1 RNAs from the nucleus to the cytoplasm, in the translation of HIV-1 transcripts, and in the packaging of viral genomic RNAs are reviewed in brief.
Keywords: Rev; CRM1; DDX3; RNA export; RNA translation; RNA packaging Rev; CRM1; DDX3; RNA export; RNA translation; RNA packaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Jeang, K.-T. Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev. Biology 2012, 1, 165-174.

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