Height and Active Arterial Wall Thickening in Relation to Thyroid Cysts Status among Elderly Japanese: A Prospective Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Data Collection and Laboratory Measurements
2.3. Statistical Analysis
3. Results
3.1. Clinical Characteristics of the Study Population
3.2. Association between Active Arterial Wall Thickening and Baseline Atherosclerosis
3.3. Association between Active Arterial Wall Thickening and Height
3.4. Additional Sensitivity Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Shimizu, Y.; Yoshimine, H.; Nagayoshi, M.; Kadota, K.; Takahashi, K.; Izumino, K.; Inoue, K.; Maeda, T. Short stature is an inflammatory disadvantage among middle-aged Japanese men. Environ. Health Prev. Med. 2016, 21, 361–367. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, Y.; Hayakawa, H.; Sasaki, N.; Takada, M.; Okada, T.; Kiyama, M. Association between height and hypertension: A retrospective study. BioMed 2022, 2, 303–309. [Google Scholar] [CrossRef]
- Daub, K.; Langer, H.; Seizer, P.; Stellos, K.; May, A.E.; Goyal, P.; Bigalke, B.; Schönberger, T.; Geisler, T.; Siegel-Axel, D.; et al. Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells. FASEB J. 2006, 20, 2559–2561. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shi, Q.; Rafii, S.; Wu, M.H.; Wijelath, E.S.; Yu, C.; Ishida, A.; Fujita, Y.; Kothari, S.; Mohle, R.; Sauvage, L.R.; et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998, 92, 362–367. [Google Scholar] [CrossRef] [PubMed]
- Stellos, K.; Langer, H.; Daub, K.; Schoenberger, T.; Gauss, A.; Geisler, T.; Bigalke, B.; Mueller, I.; Schumm, M.; Schaefer, I.; et al. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation 2008, 117, 206–215. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shimizu, Y.; Kawashiri, S.Y.; Kiyoura, K.; Koyamatsu, J.; Fukui, S.; Tamai, M.; Nobusue, K.; Yamanashi, H.; Nagata, Y.; Maeda, T. Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study. Sci. Rep. 2020, 10, 4656. [Google Scholar] [CrossRef] [Green Version]
- Shimizu, Y.; Yamanashi, H.; Noguchi, Y.; Koyamatsu, J.; Nagayoshi, M.; Kiyoura, K.; Fukui, S.; Tamai, M.; Kawashiri, S.Y.; Arima, K.; et al. Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: A cross-sectional study. Aging (Albany NY) 2019, 11, 663–672. [Google Scholar] [CrossRef]
- Shimizu, Y.; Sato, S.; Koyamatsu, J.; Yamanashi, H.; Nagayoshi, M.; Kadota, K.; Maeda, T. Height is an indicator of vascular maintenance capacity in older men. Geriatr. Gerontol. Int. 2017, 17, 1729–1736. [Google Scholar] [CrossRef]
- Shakoor, S.K.; Aldibbiat, A.; Ingoe, L.E.; Campbell, S.C.; Sibal, L.; Shaw, J.; Home, P.D.; Razvi, S.; Weaver, J.U. Endothelial progenitor cells in subclinical hypothyroidism: The effect of thyroid hormone replacement therapy. J. Clin. Endocrinol. Metab. 2010, 95, 319–322. [Google Scholar] [CrossRef] [Green Version]
- Shimizu, Y.; Nabeshima-Kimura, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nagata, Y.; Maeda, T.; Hayashida, N. Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: A cross-sectional study. Environ. Health Prev. Med. 2020, 25, 7. [Google Scholar] [CrossRef]
- Shimizu, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nagata, Y.; Maeda, T.; Hayashida, N. Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts. PLoS ONE 2020, 15, e0240198. [Google Scholar] [CrossRef]
- Shimizu, Y.; Nabeshima-Kimura, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nagata, Y.; Maeda, T.; Hayashida, N. Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: A cross-sectional study. Environ. Health Prev. Med. 2020, 25, 69. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nakamichi, S.; Nagata, Y.; Hayashida, N.; Maeda, T. Normal anti-thyroid peroxidase antibody (TPO-Ab) titers and active arterial wall thickening among euthyroid individuals: A prospective study. J. Clin. Med 2022, 11, 521. [Google Scholar] [CrossRef] [PubMed]
- Zhao, Y.; Zhang, M.; Liu, Y.; Sun, H.; Sun, X.; Yin, Z.; Li, H.; Ren, Y.; Liu, D.; Liu, F.; et al. Adult height and risk of death from all-cause, cardiovascular, and cancer-specific disease: The Rural Chinese Cohort Study. Nutr. Metab. Cardiovasc. Dis. 2019, 29, 1299–1307. [Google Scholar] [CrossRef] [PubMed]
- Patel, R.S.; Li, Q.; Ghasemzadeh, N.; Eapen, D.J.; Moss, L.D.; Janjua, A.U.; Manocha, P.; Kassem, H.A.; Veledar, E.; Samady, H.; et al. Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease. Circ. Res. 2015, 116, 289–297. [Google Scholar] [CrossRef] [Green Version]
- Mandraffino, G.; Aragona, C.O.; Basile, G.; Cairo, V.; Mamone, F.; Morace, C.; D’Ascola, A.; Alibrandi, A.; Lo Gullo, A.; Loddo, S.; et al. CD34+ cell count predicts long lasting life in the oldest old. Mech. Ageing. Dev 2017, 164, 139–145. [Google Scholar] [CrossRef]
- Shimizu, Y.; Maeda, T. Influence of height on endothelial maintenance activity: A narrative review. Environ. Health Prev. Med. 2021, 26, 19. [Google Scholar] [CrossRef]
- National Institute of Population and Social Security Research. Available online: http://www.ipss.go.jp/pp-shicyoson/j/shicyoson13/5fusa/Municipalities.asp (accessed on 26 October 2022).
- Hara, T.; Takamura, N.; Akashi, S.; Nakazato, M.; Maeda, T.; Wada, M.; Nakashima, K.; Abe, Y.; Kusano, Y.; Aoyagi, K. Evaluation of clinical markers of atherosclerosis in young and elderly Japanese adults. Clin. Chem. Lab. Med. 2006, 44, 824–829. [Google Scholar] [CrossRef]
- Yanase, T.; Nasu, S.; Mukuta, Y.; Shimizu, Y.; Nishihara, T.; Okabe, T.; Nomura, M.; Inoguchi, T.; Nawata, H. Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope. Am. J. Hypertens. 2006, 19, 1206–1212. [Google Scholar] [CrossRef] [Green Version]
- Kawamori, R.; Yamasaki, Y.; Matsushima, H.; Nishizawa, H.; Nao, K.; Hougaku, H.; Maeda, H.; Handa, N.; Matsumoto, M.; Kamada, T. Prevalence of carotid atherosclerosis in diabetic patients. Ultrasound high-resolution B mode imaging on carotid arteries. Diabetes Care 1992, 15, 1290–1294. [Google Scholar] [CrossRef]
- Lee, C.M.; Barzi, F.; Woodward, M.; Batty, G.D.; Giles, G.G.; Wong, J.W.; Jamrozik, K.; Lam, T.H.; Ueshima, H.; Kim, H.C.; et al. Asia Pacific Cohort Studies Collaboration. Adult height and the risk of cardiovascular disease and major causes of death in the Asia-Pacific region: 21,000 deaths in 510,000 men and women. Int. J. Epidemiol. 2009, 38, 1060–1071. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Honjo, K.; Iso, H.; Inoue, M.; Tsugane, S. Adult height and the risk of cardiovascular disease among middle aged men and women in Japan. Eur. J. Epidemiol. 2011, 26, 13–21. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, Y.; Sato, S.; Koyamatsu, J.; Yamanashi, H.; Nagayoshi, M.; Kadota, K.; Kawashiri, S.Y.; Maeda, T. Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men. Oncotarget 2017, 23, 7749–7757. [Google Scholar] [CrossRef] [Green Version]
- Shimizu, Y.; Kawashiri, S.Y.; Nobusue, K.; Nonaka, F.; Tamai, M.; Honda, Y.; Yamanashi, H.; Nakamichi, S.; Kiyama, M.; Hayashida, N.; et al. Association between circulating CD34-positive cell count and height loss among older men. Sci. Rep. 2022, 12, 7175. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, Y.; Hayakawa, H.; Takada, M.; Okada, T.; Kiyama, M. Hemoglobin and adult height loss among Japanese workers: A retrospective study. PLoS ONE 2021, 16, e0256281. [Google Scholar] [CrossRef] [PubMed]
- Al-Shaer, M.H.; Choueiri, N.E.; Correia, M.L.; Sinkey, C.A.; Barenz, T.A.; Haynes, W.G. Effect of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans. Int. J. Cardiol. 2006, 109, 201–206. [Google Scholar] [CrossRef]
- Shimizu, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nagata, Y.; Maeda, T.; Hayashida, N. Association between thyroid cysts and hypertension by atherosclerosis status: A cross-sectional study. Sci. Rep. 2021, 11, 13922. [Google Scholar] [CrossRef]
- Shimizu, Y.; Sato, S.; Koyamatsu, J.; Yamanashi, H.; Nagayoshi, M.; Kadota, K.; Maeda, T. Height indicates hematopoietic capacity in elderly Japanese men. Aging (Albany NY) 2016, 8, 2407–2413. [Google Scholar] [CrossRef] [Green Version]
- Shimizu, Y.; Nakazato, M.; Sekita, T.; Kadota, K.; Miura, Y.; Arima, K.; Yamasaki, H.; Goto, H.; Takamura, N.; Aoyagi, K.; et al. Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: The Nagasaki Islands study. Aging Male 2015, 18, 100–105. [Google Scholar] [CrossRef]
- Shimizu, Y.; Yoshimine, H.; Nagayoshi, M.; Kadota, K.; Takahashi, K.; Izumino, K.; Inoue, K.; Maeda, T. Height correlates with dyslipidemia in non-overweight middle-aged Japanese men. J. Physiol. Anthropol. 2016, 35, 29. [Google Scholar] [CrossRef]
- Shimizu, Y.; Yamanashi, H.; Noguchi, Y.; Koyamatsu, J.; Nagayoshi, M.; Kiyoura, K.; Fukui, S.; Tamai, M.; Kawashiri, S.Y.; Arima, K.; et al. Short stature-related single nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese. Environ. Health. Prev. Med. 2019, 24, 26. [Google Scholar] [CrossRef] [PubMed]
- Lorenz, M.W.; Polak, J.F.; Kavousi, M.; Mathiesen, E.B.; Völzke, H.; Tuomainen, T.P.; Sander, D.; Plichart, M.; Catapano, A.L.; Robertson, C.M.; et al. PROG-IMT Study Group. Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): A meta-analysis of individual participant data. Lancet 2012, 379, 2053–2062. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bots, M.L.; Grobbee, D.E. Intima media thickness as a surrogate marker for generalised atherosclerosis. Cardiovasc. Drug. Ther. 2002, 16, 341–351. [Google Scholar] [CrossRef] [PubMed]
- Van den Oord, S.C.; Sijbrands, E.J.; ten Kate, G.L.; van Klaveren, D.; van Domburg, R.T.; van der Steen, A.F.; Schinkel, A.F. Carotid intima-media thickness for cardiovascular risk assessment: Systematic review and meta-analysis. Atherosclerosis 2013, 228, 1–11. [Google Scholar] [CrossRef] [PubMed]
- Makadia, M.G.; Patel, V.I.; Patel, K.P.; Shah, A.D.; Chaudhari, K.S.; Shah, H.N.; Nilayangode, H.N. Study of glycated haemoglobin (HbA1c) in non-diabetic subjects with subclinical hypothyroidism. J. Clin. Diagn. Res. 2017, 11, BC01–BC04. [Google Scholar] [CrossRef]
- Shimizu, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nagata, Y.; Maeda, T.; Hayashida, N. HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study. PLoS ONE 2021, 16, e0253841. [Google Scholar] [CrossRef]
- Shimizu, Y.; Kawashiri, S.Y.; Noguchi, Y.; Nakamichi, S.; Nagata, Y.; Hayashida, N.; Maeda, T. Associations among ratio of free triiodothyronine to free thyroxine, chronic kidney disease, and subclinical hypothyroidism. J. Clin. Med. 2022, 11, 1269. [Google Scholar] [CrossRef]
- Yuasa, R.; Ohashi, Y.; Saito, A.; Tsuboi, K.; Shishido, S.; Sakai, K. Prevalence of hypothyroidism in Japanese chronic kidney disease patients. Ren. Fail. 2020, 42, 572–579. [Google Scholar] [CrossRef]
- Cravedi, P.; Remuzzi, G. Pathophysiology of proteinuria and its value as an outcome measure in chronic kidney disease. Br. J. Clin. Pharmacol. 2013, 76, 516–523. [Google Scholar] [CrossRef] [Green Version]
- Zhang, Y.; Chang, Y.; Ryu, S.; Cho, J.; Lee, W.Y.; Rhee, E.J.; Kwon, M.J.; Pastor-Barriuso, R.; Rampal, S.; Han, W.K.; et al. Thyroid hormone levels and incident chronic kidney disease in euthyroid individuals: The Kangbuk Samsung Health Study. Int. J. Epidemiol. 2014, 43, 1624–1632. [Google Scholar] [CrossRef]
- Shimizu, Y.; Nabeshima-Kimura, Y.; Kawashiri, S.Y.; Noguchi, Y.; Minami, S.; Nagata, Y.; Maeda, T.; Hayashida, N. Association between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population. J. Physiol. Anthropol. 2021, 40, 15. [Google Scholar] [CrossRef] [PubMed]
- Saito, I.; Yonemasu, K.; Inami, F. Association of body mass index, body fat, and weight gain with inflammation markers among rural residents in Japan. Circ. J. 2003, 67, 323–329. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ungvari, Z.; Tarantini, S.; Donato, A.J.; Galvan, V.; Csiszar, A. Mechanisms of vascular aging. Circ. Res. 2018, 123, 849–867. [Google Scholar] [CrossRef]
- Soliman, A.T.; De Sanctis, V.; Kalra, S. Anemia and growth. Indian J. Endocrinol. Metab. 2014, 18, S1–S5. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, Y.; Kawashiri, S.Y.; Yamanashi, H.; Koyamatsu, J.; Fukui, S.; Kondo, H.; Tamai, M.; Nakamichi, S.; Maeda, T. Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: A cross-sectional study. Clin. Interv. Aging 2019, 14, 849–857. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shimizu, Y.; Sato, S.; Noguchi, Y.; Koyamatsu, J.; Yamanashi, H.; Higashi, M.; Nagayoshi, M.; Kadota, K.; Kawashiri, S.Y.; Nagata, Y.; et al. Impact of single nucleotide polymorphism on short stature and reduced tongue pressure among community-dwelling elderly Japanese participants: A cross-sectional study. Environ. Health Prev. Med. 2017, 22, 62. [Google Scholar] [CrossRef] [Green Version]
- Nelson, C.P.; Hamby, S.E.; Saleheen, D.; Hopewell, J.C.; Zeng, L.; Assimes, T.L.; Kanoni, S.; Willenborg, C.; Burgess, S.; Amouyel, P.; et al. CARDIoGRAM+C4D Consortium. Genetically determined height and coronary artery disease. N. Engl. J. Med. 2015, 372, 1608–1618. [Google Scholar] [CrossRef] [Green Version]
- Trenkwalder, T.; Kessler, T.; Schunkert, H.; Erdmann, J. Genetics of coronary artery disease: Short people at risk? Expert Rev. Cardiovasc. Ther. 2015, 13, 1169–1172. [Google Scholar] [CrossRef] [Green Version]
- Kim, M.J.; Kim, M.H.; Kim, S.A.; Chang, J.S. Age-related deterioration of hematopoietic stem cells. Int. J. Stem Cells 2008, 1, 55–63. [Google Scholar] [CrossRef] [Green Version]
- Brusnahan, S.K.; McGuire, T.R.; Jackson, J.D.; Lane, J.T.; Garvin, K.L.; O’Kane, B.J.; Berger, A.M.; Tuljapurkar, S.R.; Kessinger, M.A.; Sharp, J.G. Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines. Mech. Ageing Dev. 2010, 131, 718–722. [Google Scholar] [CrossRef]
- Guralnik, J.M.; Ershler, W.B.; Schrier, S.L.; Picozzi, V.J. Anemia in the elderly: A public health crisis in hematology. Hematology. Am. Soc. Hematol. Educ. Program 2005, 1, 528–532. [Google Scholar] [CrossRef] [Green Version]
- Cooper, B. The origins of bone marrow as the seedbed of our blood: From antiquity to the time of Osler. Proc. (Bayl. Univ. Med. Cent.) 2011, 24, 115–118. [Google Scholar] [CrossRef] [PubMed]
- Garvin, K.; Feschuk, C.; Sharp, J.G.; Berger, A. Does the number or quality of pluripotent bone marrow stem cells decrease with age? Clin. Orthop. Relat. Res. 2007, 465, 202–207. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, Y.; Imano, H.; Ohira, T.; Kitamura, A.; Kiyama, M.; Okada, T.; Ishikawa, Y.; Shimamoto, T.; Yamagishi, K.; Tanigawa, T.; et al. CIRCS Investigators. Adult height and body mass index in relation to risk of total stroke and its subtypes: The circulatory risk in communities study. J. Stroke Cerebrovasc. Dis. 2014, 23, 667–674. [Google Scholar] [CrossRef] [PubMed]
- Hozawa, A.; Murakami, Y.; Okamura, T.; Kadowaki, T.; Nakamura, K.; Hayakawa, T.; Kita, Y.; Nakamura, Y.; Okayama, A.; Ueshima, H. NIPPON DATA80 Research Group. Relation of adult height with stroke mortality in Japan: NIPPON DATA80. Stroke 2007, 38, 22–26. [Google Scholar] [CrossRef] [Green Version]
- Sawada, N.; Wark, P.A.; Merritt, M.A.; Tsugane, S.; Ward, H.A.; Rinaldi, S.; Weiderpass, E.; Dartois, L.; His, M.; Boutron-Ruault, M.C.; et al. The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC). PLoS ONE 2017, 12, e0173117. [Google Scholar] [CrossRef] [Green Version]
- Ong, J.S.; An, J.; Law, M.H.; Whiteman, D.C.; Neale, R.E.; Gharahkhani, P.; MacGregor, S. Height and overall cancer risk and mortality: Evidence from a Mendelian randomisation study on 310,000 UK Biobank participants. Br. J. Cancer 2018, 118, 1262–1267. [Google Scholar] [CrossRef]
- Mugikura, M.; Sugawara, Y.; Tomata, Y.; Kanemura, S.; Fukao, A.; Tsuji, I. Association between adult height and risk of lung cancer incidence among Japanese men: The Miyagi Cohort Study. Tohoku J. Exp. Med. 2020, 251, 51–59. [Google Scholar] [CrossRef]
Height Tertile | p | ||||
---|---|---|---|---|---|
Tertile 1 (Low) | Tertile 2 (Middle) | Tertile 3 (High) | |||
Total | |||||
No. of participants | 244 | 251 | 245 | ||
Men, % | 40.6 | 39.8 | 40.8 | 0.974 | |
Age, year | 65.4 ± 2.7 | 65.3 ± 2.6 | 64.8 ± 2.5 | 0.047 | |
free T3, pmol/L | 4.87 ± 0.48 | 4.90 ± 0.52 | 4.86 ± 0.51 | 0.663 | |
free T4, pmol/L | 0.16 ± 0.02 | 0.16 ± 0.02 | 0.16 ± 0.02 | 0.429 | |
TSH, mIU/L | 1.72 [1.23, 2.48] *1 | 1.53 [1.10, 2.35] *1 | 1.47 [1.08, 2.31] *1 | 0.044 *2 | |
CIMT, mm | 0.86 [0.75, 0.97] *1 | 0.84 [0.76, 0.96] *1 | 0.85 [0.77, 0.99] *1 | 0.370 *2 | |
Thyroid cyst (−) | |||||
No. of participants | 164 | 157 | 151 | ||
Men, % | 49.3 | 49.9 | 50.0 | 0.466 | |
Age, year | 65.4 ± 2.7 | 65.2 ± 2.5 | 64.8 ± 2.6 | 0.211 | |
free T3, pmol/L | 4.88 ± 0.45 | 4.86 ± 0.55 | 4.93 ± 0.50 | 0.392 | |
free T4, pmol/L | 0.16 ± 0.03 | 0.16 ± 0.03 | 0.16 ± 0.02 | 0.707 | |
TSH, mIU/L | 1.70 [1.22, 2.41] *1 | 1.47 [1.09, 2.37] *1 | 1.48 [1.09, 2.35] *2 | 0.260 *2 | |
CIMT, mm | 0.85 [0.75, 0.97] *1 | 0.84 [0.76, 0.95] *1 | 0.85 [0.76, 0.98] *2 | 0.809 *2 | |
Thyroid cyst (+) | |||||
No. of participants | 80 | 94 | 94 | ||
Men, % | 49.3 | 46.4 | 46.0 | 0.304 | |
Age, year | 65.3 ± 2.7 | 65.5 ± 2.7 | 64.8 ± 2.4 | 0.140 | |
free T3, pmol/L | 4.86 ± 0.53 | 4.98 ± 0.47 | 4.75 ± 0.50 | 0.008 | |
freeT4, pmol/L | 0.16 ± 0.02 | 0.15 ± 0.02 | 0.16 ± 0.02 | 0.331 | |
TSH, mIU/L | 1.75 [1.36, 2.87] *1 | 1.67 [1.12, 2.35] *2 | 1.45 [1.08, 2.22] *1 | 0.118 *2 | |
CIMT, mm | 0.88 [0.75, 0.98] *1 | 0.86 [0.77, 0.99] *1 | 0.85 [0.78, 1.04] *1 | 0.370 *2 |
Baseline Atherosclerosis | p | ||
---|---|---|---|
(−) | (+) | ||
No. of participants | 644 | 96 | |
No. of cases (%) | 299 (46.4) | 7 (7.3) | |
Model 1 | Ref | 0.09 (0.04, 0.20) | <0.001 |
Model 2 | Ref | 0.09 (0.04, 0.20) | <0.001 |
Model 3 | Ref | 0.09 (0.04, 0.20) | <0.001 |
Height Tertile | p for Trend | 1SD Increment in Height (5.7 cm for Men and 4.8 cm for Women) | |||
---|---|---|---|---|---|
Tertile 1 (Low) | Tertile 2 (Middle) | Tertile 3 (High) | |||
Total | |||||
No. of participants | 244 | 251 | 245 | ||
No. of cases (%) | 105 (43.0) | 100 (39.8) | 101 (41.2) | ||
Model 1 | Ref | 0.88 (0.61, 1.25) | 0.93 (0.65, 1.33) | 0.685 | 0.94 (0.81, 1.09) |
Model 2 | Ref | 0.88 (0.61, 1.25) | 0.92 (0.64, 1.32) | 0.663 | 0.94 (0.81, 1.09) |
Model 3 | Ref | 0.87 (0.61, 1.24) | 0.91 (0.64, 1.31) | 0.620 | 0.94 (0.81, 1.09) |
Model 4 | Ref | 0.86 (0.58, 1.27) | 0.99 (0.67, 1.46) | 0.941 | 0.99 (0.83, 1.16) |
Thyroid cyst (−) | |||||
No. of participants | 164 | 157 | 151 | ||
No. of cases (%) | 62 (37.8) | 63 (40.1) | 70 (46.4) | ||
Model 1 | Ref | 1.11 (0.70, 1.73) | 1.42 (0.91, 2.23) | 0.126 | 1.12 (0.93, 1.35) |
Model 2 | Ref | 1.10 (0.71, 1.73) | 1.43 (0.91, 2.24) | 0.126 | 1.12 (0.93, 1.35) |
Model 3 | Ref | 1.11 (0.71, 1.74) | 1.43 (0.91, 1.74) | 0.126 | 1.12 (0.93, 1.35) |
Model 4 | Ref | 1.09 (0.67, 1.77) | 1.62 (0.98, 2.68) | 0.061 | 1.19 (0.96, 1.50) |
Thyroid cyst (+) | |||||
No. of participants | 80 | 94 | 94 | ||
No. of cases (%) | 43 (53.8) | 37 (39.4) | 31 (33.0) | ||
Model 1 | Ref | 0.56 (0.31, 1.02) | 0.42 (0.23, 0.78) | 0.007 | 0.69 (0.57, 0.89) |
Model 2 | Ref | 0.54 (0.29, 0.995) | 0.40 (0.21, 0.75) | 0.004 | 0.67 (0.51, 0.86) |
Model 3 | Ref | 0.48 (0.26, 0.91) | 0.32 (0.17, 0.62) | <0.001 | 0.62 (0.48, 0.82) |
Model 4 | Ref | 0.47 (0.24, 0.94) | 0.33 (0.16, 0.67) | 0.002 | 0.66 (0.49, 0.89) |
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Shimizu, Y.; Kawashiri, S.-Y.; Noguchi, Y.; Nakamichi, S.; Nagata, Y.; Maeda, T.; Hayashida, N. Height and Active Arterial Wall Thickening in Relation to Thyroid Cysts Status among Elderly Japanese: A Prospective Study. Biology 2022, 11, 1756. https://doi.org/10.3390/biology11121756
Shimizu Y, Kawashiri S-Y, Noguchi Y, Nakamichi S, Nagata Y, Maeda T, Hayashida N. Height and Active Arterial Wall Thickening in Relation to Thyroid Cysts Status among Elderly Japanese: A Prospective Study. Biology. 2022; 11(12):1756. https://doi.org/10.3390/biology11121756
Chicago/Turabian StyleShimizu, Yuji, Shin-Ya Kawashiri, Yuko Noguchi, Seiko Nakamichi, Yasuhiro Nagata, Takahiro Maeda, and Naomi Hayashida. 2022. "Height and Active Arterial Wall Thickening in Relation to Thyroid Cysts Status among Elderly Japanese: A Prospective Study" Biology 11, no. 12: 1756. https://doi.org/10.3390/biology11121756