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Biology 2013, 2(1), 26-39; doi:10.3390/biology2010026

Gene Expression and Regulation in Adrenocortical Tumorigenesis

1
Department of Surgery, Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, 333 Cedar Street, TMP202 Box 208062, New Haven, CT 06520, USA
2
Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
Received: 31 October 2012 / Revised: 1 December 2012 / Accepted: 14 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Gene Expression and Regulation)
View Full-Text   |   Download PDF [170 KB, uploaded 27 December 2012]

Abstract

Adrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the absence of widely invasive or metastatic disease, and hence attention has turned towards a search for molecular markers. The study of rare genetic diseases that are associated with the development of adrenocortical carcinomas has contributed to our understanding of adrenocortical tumorigenesis. In addition, comprehensive genomic hybridization, methylation profiling, and genome wide mRNA and miRNA profiling have led to improvements in our understanding, as well as demonstrated several genes and pathways that may serve as diagnostic or prognostic markers.
Keywords: adrenocortical tumor; epigenetics; gene expression; genetics adrenocortical tumor; epigenetics; gene expression; genetics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Fonseca, A.L.; Healy, J.; Kunstman, J.W.; Korah, R.; Carling, T. Gene Expression and Regulation in Adrenocortical Tumorigenesis. Biology 2013, 2, 26-39.

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